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http://hdl.handle.net/2445/54185
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DC Field | Value | Language |
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dc.contributor.author | Gao, Su | - |
dc.contributor.author | Serra i Cucurull, Dolors | - |
dc.contributor.author | Keung, Wendy | - |
dc.contributor.author | García Hegardt, Fausto | - |
dc.contributor.author | Lopaschuk, Gary D. | - |
dc.date.accessioned | 2014-05-19T13:16:55Z | - |
dc.date.issued | 2013-08-01 | - |
dc.identifier.issn | 0193-1849 | - |
dc.identifier.uri | http://hdl.handle.net/2445/54185 | - |
dc.description.abstract | Carnitine palmitoyltransferase-1 (CPT-1) liver isoform or CPT-1a is implicated in CNS control of food intake. However, the exact brain nucleus site(s) in mediating this action of CPT-1a has not been identified. In this report, we assess the role of CPT-1a in hypothalamic ventromedial nucleus (VMN). We stereotaxically injected an adenoviral vector containing CPT-1a coding sequence into the VMN of rats to induce overexpression and activation of CPT-1a. The VMN-selective activation of CPT-1a induced orexigenic effect, suggesting CPT-1a in the VMN is involved in the central control of feeding. Intracerebroventricular administration of etomoxir, a CPT-1 inhibitor, decreases food intake. Importantly, in the animals with VMN-overexpression of a CPT-1a mutant that antagonizes the CPT-1 inhibition by etomoxir, the anorectic response to etomoxir was attenuated. This suggests that VMN is involved in mediating the anorectic effect of central inhibition of CPT-1a. In contrast, Arc overexpression of the mutant did not alter etomoxir-induced inhibition of food intake, suggesting that Arc CPT-1a does not play significant roles in this anorectic action. Furthermore, in the VMN, CPT-1a appears to act downstream of hypothalamic malonyl-CoA action of feeding. Finally, we show that in the VMN, CPT-1 activity altered in concert with fasting and refeeding states, supporting a physiological role of CPT-1a in mediating the control of feeding. Taking together, CPT-1a in the hypothalamic VMN appears to play an important role in the central control of food intake. VMN-selective modulation of CPT-1a activity may therefore be a promising strategy in controlling food intake and maintaining normal body weight. | - |
dc.format.extent | 31 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | American Physiological Society | - |
dc.relation.isformatof | Versió postprint del document publicat a: http://dx.doi.org/10.1152/ajpendo.00168.2013 | - |
dc.relation.ispartof | American Journal of Physiology-Endocrinology and Metabolism, 2013, vol. 305, num. 3, p. E336-E347 | - |
dc.relation.uri | http://dx.doi.org/10.1152/ajpendo.00168.2013 | - |
dc.rights | (c) American Physiological Society, 2013 | - |
dc.source | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) | - |
dc.subject.classification | Nutrició | - |
dc.subject.classification | Fisiologia | - |
dc.subject.classification | Hipotàlem | - |
dc.subject.classification | Carnitina palmitoïl-transferasa 1 | - |
dc.subject.other | Nutrition | - |
dc.subject.other | Physiology | - |
dc.subject.other | Hypothalamus | - |
dc.subject.other | Carnitine palmitoyltransferase I | - |
dc.title | Important role of ventromedial hypothalamic carnitine palmitoyltransferase-1a in the control of food intake | eng |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 637821 | - |
dc.date.updated | 2014-05-16T10:51:45Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) |
Files in This Item:
File | Description | Size | Format | |
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637821.pdf | 408.22 kB | Adobe PDF | View/Open |
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