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Title: | Evidence of an efflux pump in Serratia marcescens |
Author: | Berlanga Herranz, Mercedes Vázquez, J. L. Borrell Hernández, Jordi Montero Barrientos, Ma. Teresa Viñas, Miquel |
Keywords: | Resistència als medicaments Antibiòtics Serratia marcescens Medicaments antibacterians Drug resistance Antibiotics Serratia marcescens |
Issue Date: | 7-Jul-2000 |
Publisher: | Mary Ann Liebert, Inc. |
Abstract: | Spontaneous mutants resistant to fluoroquinolones were obtained by exposing Serratia marcescens NIMA (wild-type strain) to increasing concentrations of ciprofloxacin both in liquid and on solid media. Frequencies of mutation ranged from 10-7 to 10-9. Active expulsion of antibiotic was explored as a possible mechanism of resistance in mutants as well as changes in topoisomerase target genes. The role of extrusion mechanisms in determining the emergence of multidrug-resistant bacteria was also examined. Mutants resistant to high concentrations of fluoroquinolones had a single mutation in their gyrA QRDR sequences, whereas the moderate resistance in the rest of mutants was due to extrusion of the drug |
Note: | Reproducció del document publicat a: http://dx.doi.org/10.1089/107662900419410 |
It is part of: | Microbial Drug Resistance, 2000, vol. 6, num. 2, p. 111-117 |
URI: | http://hdl.handle.net/2445/54944 |
Related resource: | http://dx.doi.org/10.1089/107662900419410 |
ISSN: | 1076-6294 |
Appears in Collections: | Articles publicats en revistes (Patologia i Terapèutica Experimental) Articles publicats en revistes (Biologia, Sanitat i Medi Ambient) Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica) |
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