Highly efficient, multigram and enantiopure synthesis of (S)-2-(2,4′-bithiazol-2-yl)pyrrolidine

Just Baringo, Xavier; Bruno, Paolo; Albericio Palomera, Fernando; Álvarez Domingo, Mercedes

Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/54982

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DC Field	Value	Language
dc.contributor.author	Just Baringo, Xavier	-
dc.contributor.author	Bruno, Paolo	-
dc.contributor.author	Albericio Palomera, Fernando	-
dc.contributor.author	Álvarez Domingo, Mercedes	-
dc.date.accessioned	2014-06-13T10:51:08Z	-
dc.date.available	2014-06-13T10:51:08Z	-
dc.date.issued	2011-08-16	-
dc.identifier.issn	0040-4039	-
dc.identifier.uri	https://hdl.handle.net/2445/54982	-
dc.description.abstract	(S)-2-(4-Bromo-2,4"-bithiazole)-1-(tert-butoxycarbonyl)pyrrolidine ((S)-1) was obtained as a single enantiomer and in high yield by means of a two-step modified Hantzsch thiazole synthesis reaction when bromoketone 3 and thioamide (S)-4 were used. Further conversion of (S)-1 into trimethyltin derivative (S)-2 broadens the scope for further cross-coupling reactions.	-
dc.format.extent	3 p.	-
dc.format.mimetype	application/pdf	-
dc.language.iso	eng	-
dc.publisher	Elsevier Ltd	-
dc.relation.isformatof	Versió postprint del document publicat a: http://dx.doi.org/10.1016/j.tetlet.2011.07.128	-
dc.relation.ispartof	Tetrahedron Letters, 2011, vol. 52, num. 42, p. 5435-5437	-
dc.relation.uri	http://dx.doi.org/10.1016/j.tetlet.2011.07.128	-
dc.rights	(c) Elsevier Ltd, 2011	-
dc.source	Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)	-
dc.subject.classification	Productes naturals	-
dc.subject.classification	Antibiòtics	-
dc.subject.classification	Síntesi de pèptids	-
dc.subject.classification	Compostos heterocíclics	-
dc.subject.classification	Enantiòmers	-
dc.subject.other	Natural products	-
dc.subject.other	Antibiotics	-
dc.subject.other	Peptide synthesis	-
dc.subject.other	Heterocyclic compounds	-
dc.subject.other	Enantiomers	-
dc.title	Highly efficient, multigram and enantiopure synthesis of (S)-2-(2,4′-bithiazol-2-yl)pyrrolidine	-
dc.type	info:eu-repo/semantics/article	-
dc.type	info:eu-repo/semantics/acceptedVersion	-
dc.identifier.idgrec	598512	-
dc.date.updated	2014-06-13T10:51:08Z	-
dc.rights.accessRights	info:eu-repo/semantics/openAccess	-
Appears in Collections:	Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

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