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http://hdl.handle.net/2445/55263
Title: | Isolation, structural assignment and total synthesis of Barmumycin |
Author: | Lorente Crivillé, Adriana Pla Queral, Daniel Cañedo, Librada M. Albericio Palomera, Fernando Álvarez Domingo, Mercedes |
Keywords: | Medicaments antineoplàstics Productes naturals marins Lactones Imidazoles Antineoplastic agents Marine natural products Lactones Imidazoles |
Issue Date: | 23-Nov-2010 |
Publisher: | American Chemical Society |
Abstract: | Barmumycin was isolated from an extract of the marine actinomycete Streptomyces sp. BOSC-022A and found to be cytotoxic against various human tumor cell lines. Based on preliminary one- and two-dimensional 1H- and 13C-NMR spectra, the natural compound was initially assigned the structure of macrolactone-type compound 1, which was later prepared by two different routes. However, major spectroscopic differences between isolated barmumycin and 1 led to revision of the proposed structure as E-16. Based on synthesis of this new compound, and subsequent spectroscopic comparison of it to an authentic sample of barmumycin, the structure of the natural compound was indeed confirmed as that of E-16. |
Note: | Versió postprint del document publicat a: http://dx.doi.org/10.1021/jo101834c |
It is part of: | Journal of Organic Chemistry, 2010, vol. 75, num. 24, p. 8508-8515 |
URI: | http://hdl.handle.net/2445/55263 |
Related resource: | http://dx.doi.org/10.1021/jo101834c |
ISSN: | 0022-3263 |
Appears in Collections: | Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) |
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