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http://hdl.handle.net/2445/55270
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DC Field | Value | Language |
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dc.contributor.author | Domenech Pena, Arnau | - |
dc.contributor.author | Cabellos Mínguez, Ma. Carmen | - |
dc.contributor.author | Ribes Miravet, Sandra | - |
dc.contributor.author | Tubau, Fe | - |
dc.contributor.author | Viladrich, Pedro F. | - |
dc.contributor.author | Liñares Louzao, Josefina | - |
dc.contributor.author | Gudiol i Munté, Francesc | - |
dc.date.accessioned | 2014-06-27T09:38:50Z | - |
dc.date.available | 2014-06-27T09:38:50Z | - |
dc.date.issued | 2003-10 | - |
dc.identifier.issn | 1076-6294 | - |
dc.identifier.uri | http://hdl.handle.net/2445/55270 | - |
dc.description.abstract | The increasing incidence of ciprofloxacin resistance in Streptococcus pneumoniae may limit the efficacy of the new quinolones in difficult-to-treat infections such as meningitis. The aim of the present study was to determine the efficacy of clinafloxacin alone and in combination with teicoplanin and rifampin in the therapy of ciprofloxacin-susceptible and ciprofloxacin-resistant pneumococcal meningitis in rabbits. When used against a penicillin-resistant ciprofloxacin-susceptible strain (Clinafloxacin MIC 0.12 μg/ml), clinafloxacin at a dose of 20 mg/kg per day b.i.d. decreased bacterial concentration by -5.10 log cfu/ml at 24 hr. Combinations did not improve activity. The same clinafloxacin schedule against a penicillin- and ciprofloxacin-resistant strain (Clinafloxacin MIC 0.5 μg/ml) was totally ineffective. Our data suggest that a moderate decrease in quinolone susceptibility, as indicated by the detection of any degree of ciprofloxacin resistance, may render these antibiotics unsuitable for the management of pneumococcal meningitis | - |
dc.format.extent | 7 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Mary Ann Liebert, Inc. | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.1089/107662903322541900 | - |
dc.relation.ispartof | Microbial Drug Resistance, 2003, vol. 9, num. supl. 1, p. 53-59 | - |
dc.relation.uri | http://dx.doi.org/10.1089/107662903322541900 | - |
dc.rights | (c) Mary Ann Liebert, Inc., 2003 | - |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | Resistència als medicaments | - |
dc.subject.classification | Estreptococs | - |
dc.subject.classification | Pneumococs | - |
dc.subject.classification | Ciprofloxacina | - |
dc.subject.classification | Meningitis | - |
dc.subject.classification | Antibiòtics | - |
dc.subject.other | Drug resistance | - |
dc.subject.other | Streptococcus | - |
dc.subject.other | Streptococcus pneumonia | - |
dc.subject.other | Ciprofloxacin | - |
dc.subject.other | Meningitis | - |
dc.subject.other | Antibiotics | - |
dc.title | Experimental study of clinafloxacin alone and in combination in the treatment of ciprofloxacin-susceptible and -resistant pneumococcal meningitis | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 524521 | - |
dc.date.updated | 2014-06-27T09:38:50Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Patologia i Terapèutica Experimental) |
Files in This Item:
File | Description | Size | Format | |
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524521.pdf | 182.08 kB | Adobe PDF | View/Open |
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