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https://hdl.handle.net/2445/56045| Title: | Synthesis and antitumor activity of mechercharmycin A analogues |
| Author: | Hernández Romero, Delia Altuna, Marta Cuevas, Carmen Aligué i Alemany, Rosa Maria Albericio Palomera, Fernando Álvarez Domingo, Mercedes |
| Keywords: | Compostos heterocíclics Medicaments antineoplàstics Síntesi de pèptids Espectroscòpia de ressonància magnètica nuclear Heterocyclic compounds Antineoplastic agents Peptide synthesis Nuclear magnetic resonance spectroscopy |
| Issue Date: | 3-Sep-2008 |
| Publisher: | American Chemical Society |
| Abstract: | Several analogs of the cytotoxic thiopeptide IB-01211 or Mechercharmycin A (1) have been synthetized. The cytotoxicity of 1 and the synthetized analogs was evaluated against a panel of three human tumor cell lines. Thiopeptide 1 and the most active derivatives, 2 and 3c, were chosen for further studies like effects on cell cycle progression and induction of apoptosis. Interestingly, the inhibition of cell division and activation of a programmed cell death by apoptosis was detected. |
| Note: | Versió postprint del document publicat a: http://dx.doi.org/10.1021/jm800513w |
| It is part of: | Journal of Medicinal Chemistry, 2008, vol. 51, num. 18, p. 5722-5730 |
| URI: | https://hdl.handle.net/2445/56045 |
| Related resource: | http://dx.doi.org/10.1021/jm800513w |
| ISSN: | 0022-2623 |
| Appears in Collections: | Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| 564958.pdf | 587.13 kB | Adobe PDF | View/Open |
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