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DC Field | Value | Language |
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dc.contributor.author | Egaña Gorroño, Lander | - |
dc.contributor.author | Martínez Chamorro, Esteban José | - |
dc.contributor.author | Escribà, Tuixent | - |
dc.contributor.author | Calvo, Marta | - |
dc.contributor.author | Gatell, José M. | - |
dc.contributor.author | Arnedo, Mireia | - |
dc.date.accessioned | 2014-07-28T12:03:36Z | - |
dc.date.available | 2014-07-28T12:03:36Z | - |
dc.date.issued | 2012-12-06 | - |
dc.identifier.uri | http://hdl.handle.net/2445/56372 | - |
dc.description.abstract | Objectives: General population studies have shown associations between copy number variation (CNV) of the LPA gene Kringle-IV type-2 (KIV-2) coding region, single-nucleotide polymorphism (SNP) rs6415084 in LPA and coronary heart disease (CHD). Because risk factors for HIV-infected patients may differ from the general population, we aimed to assess whether these potential associations also occur in HIV-infected patients. Methods: A unicenter, retrospective, case-control (1:3) study. Eighteen HIV-patients with confirmed diagnosis of acute myocardial infarction (AMI) were adjusted for age, gender, and time since HIV diagnosis to 54 HIV-patients without CHD. After gDNA extraction from frozen blood, both CNV and SNP genotyping were performed using real-time quantitative PCR. All genetic and non-genetic variables for AMI were assessed in a logistic regression analysis. Results: Our results did not confirm any association in terms of lipoprotein(a) LPA structural genetic variants when comparing KIV-2 CNV (p = 0.67) and SNP genotypes (p = 0.44) between AMI cases and controls. However, traditional risk factors such as diabetes mellitus, hypertension, and CD4(+) T cell count showed association (p < 0.05) with CHD. Conclusion: Although significant associations of AMI with diabetes, hypertension and CD4(+) T cell count in HIV-patients were found, this study could not confirm the feasibility neither of KIV-2 CNV nor rs6415084 in LPA as genetic markers of CHD in HIV-infected patients.Highlights:● Individuals with HIV infection are at higher risk of coronary heart disease (CHD) than the non-infected population.● Our results showed no evidence of LPA structural genetic variants associated with CHD in HIV-1-infected patients.● Associations were found between diabetes mellitus, arterial hypertension, CD4(+) T cell count, and CHD.● The clinical usefulness of these biomarkers to predict CHD in HIV-1-infected population remains unproven.● Further studies are needed to assess the contribution of common genetic variations to CHD in HIV-infected individuals. | - |
dc.format.extent | 4 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Frontiers Media | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.3389/fimmu.2012.00367 | - |
dc.relation.ispartof | Frontiers in Immunology, 2012, vol. 3, p. 367 | - |
dc.relation.uri | http://dx.doi.org/10.3389/fimmu.2012.00367 | - |
dc.rights | cc-by (c) Egana-Gorrono, L. et al., 2012 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Malalties del cor | - |
dc.subject.classification | Lipoproteïnes | - |
dc.subject.classification | Infeccions per VIH | - |
dc.subject.classification | Sida | - |
dc.subject.other | Heart diseases | - |
dc.subject.other | Lipoproteins | - |
dc.subject.other | HIV infections | - |
dc.subject.other | AIDS (Disease) | - |
dc.title | Association study of lipoprotein(a) genetic markers, traditional risk factors, and coronary heart disease in HIV-1-infected patients. | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 627367 | - |
dc.date.updated | 2014-07-28T12:03:36Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 23230442 | - |
Appears in Collections: | Articles publicats en revistes (Medicina) |
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627367.pdf | 205.57 kB | Adobe PDF | View/Open |
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