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Title: Cardiovascular disease-related parameters and Oxidative stress in SHROB rats, a model for metabolic syndrome.
Author: Molinar Toribio, Eunice María
Pérez-Jiménez, Jara
Ramos Romero, Sara
Lluís, Laura
Sánchez-Martos, Vanessa
Taltavull, Núria
Romeu Ferran, Marta
Pazos, Manuel
Méndez, Lucía
Miranda, Aníbal
Cascante i Serratosa, Marta
Medina, Isabel
Torres, Josep Lluís
Keywords: Infermeria cardiovascular
Estrès oxidatiu
Síndrome metabòlica
Cardiovascular disease nursing
Oxidative stress
Metabolic syndrome
Issue Date: 12-Aug-2014
Publisher: Public Library of Science (PLoS)
Abstract: SHROB rats have been suggested as a model for metabolic syndrome (MetS) as a situation prior to the onset of CVD or type-2 diabetes, but information on descriptive biochemical parameters for this model is limited. Here, we extensively evaluate parameters related to CVD and oxidative stress (OS) in SHROB rats. SHROB rats were monitored for 15 weeks and compared to a control group of Wistar rats. Body weight was recorded weekly. At the end of the study, parameters related to CVD and OS were evaluated in plasma, urine and different organs. SHROB rats presented statistically significant differences from Wistar rats in CVD risk factors: total cholesterol, LDL-cholesterol, triglycerides, apoA1, apoB100, abdominal fat, insulin, blood pressure, C-reactive protein, ICAM-1 and PAI-1. In adipose tissue, liver and brain, the endogenous antioxidant systems were activated, yet there was no significant oxidative damage to lipids (MDA) or proteins (carbonylation). We conclude that SHROB rats present significant alterations in parameters related to inflammation, endothelial dysfunction, thrombotic activity, insulin resistance and OS measured in plasma as well as enhanced redox defence systems in vital organs that will be useful as markers of MetS and CVD for nutrition interventions.
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It is part of: PLoS One, 2014, vol. 9, num. 8
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ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Bioquímica i Biomedicina Molecular)
Publicacions de projectes de recerca finançats per la UE

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