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Title: Validated spectrofluorometric method for determination of gemfibrozil in self nanoemulsifying drug delivery systems (SNEDDS)
Author: Sierra Villar, Ana María
Calpena Campmany, Ana Cristina
Halbaut, Lyda
Aróztegui Trenchs, Montserrat
Clares Naveros, Beatriz
Keywords: Sistemes d'administració de medicaments
Emulsions (Farmàcia)
Solucions (Farmàcia)
Medicaments cardiovasculars
Espectroscòpia de fluorescència
Drug delivery devices
Emulsions (Pharmacy)
Solutions (Pharmacy)
Cardiovascular agents
Fluorescence spectroscopy
Issue Date: 3-May-2013
Publisher: Elsevier B.V.
Abstract: A spectrofluorometric method has been developed and validated for the determination of gemfibrozil. The method is based on the excitation and emission capacities of gemfibrozil with excitation and emission wavelengths of 276 and 304 nm respectively. This method allows de determination of the drug in a self-nanoemulsifying drug delivery system (SNEDDS) for improve its intestinal absorption. Results obtained showed linear relationships with good correlation coefficients (r(2)>0.999) and low limits of detection and quantification (LOD of 0.075 μg mL(-1) and LOQ of 0.226 μg mL(-1)) in the range of 0.2-5 μg mL(-1), equally this method showed a good robustness and stability. Thus the amounts of gemfibrozil released from SNEDDS contained in gastro resistant hard gelatine capsules were analysed, and release studies could be performed satisfactorily.
Note: Versió postprint del document publicat a:
It is part of: Spectrochimica Acta Part A-Molecular and Biomolecular Spectroscopy, 2013, vol. 113, num. September 2013, p. 22-27
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ISSN: 1386-1425
Appears in Collections:Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)

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