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http://hdl.handle.net/2445/63190
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DC Field | Value | Language |
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dc.contributor.author | Carrillo Arregui, Jokin | - |
dc.contributor.author | Gómez, Álex | - |
dc.contributor.author | Costa i Arnau, Anna M. | - |
dc.contributor.author | Fernández, Patricia | - |
dc.contributor.author | Isart Garriga, Carles | - |
dc.contributor.author | Sidera Portela, Mireia | - |
dc.contributor.author | Vilarrasa i Llorens, Jaume | - |
dc.date.accessioned | 2015-02-20T10:25:13Z | - |
dc.date.available | 2015-02-20T10:25:13Z | - |
dc.date.issued | 2014-06-21 | - |
dc.identifier.issn | 0040-4039 | - |
dc.identifier.uri | http://hdl.handle.net/2445/63190 | - |
dc.description.abstract | The esterification of fragment C1-C8 (2) with fragment C16-C23 (3) to give iodo derivative 4, followed by a Pd-catalysed coupling with a C9-C15 fragment (7 or 8), may provide a common precursor of most palmerolides. Ligands and reaction conditions were exhaustively examined to perform the C15-C16 bond formation via Negishi reaction. With simple models, pre-activated Pd-Xantphos and Pd-DPEphos complexes were the most efficient catalysts at RT. Zincation of the C9-C15 fragment (8) and cross coupling with 4 required 3 equiv of t-BuLi, 10 mol % of Pd-Xantphos and 60 °C. | - |
dc.format.extent | 5 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier Ltd | - |
dc.relation.isformatof | Versió postprint del document publicat a: http://dx.doi.org/10.1016/j.tetlet.2014.06.066 | - |
dc.relation.ispartof | Tetrahedron Letters, 2014, vol. 55, num. 33, p. 4623-4627 | - |
dc.relation.uri | http://dx.doi.org/10.1016/j.tetlet.2014.06.066 | - |
dc.rights | (c) Elsevier Ltd, 2014 | - |
dc.source | Articles publicats en revistes (Química Inorgànica i Orgànica) | - |
dc.subject.classification | Melanoma | - |
dc.subject.classification | Antibiòtics | - |
dc.subject.classification | Quimioinformàtica | - |
dc.subject.classification | Química organometàl·lica | - |
dc.subject.other | Melanoma | - |
dc.subject.other | Antibiotics | - |
dc.subject.other | Cheminformatics | - |
dc.subject.other | Organometallic chemistry | - |
dc.title | A synthetic approach to palmerolides via Negishi cross coupling. The challenge of the C15-C16 bond formation | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 646925 | - |
dc.date.updated | 2015-02-20T10:25:13Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Química Inorgànica i Orgànica) |
Files in This Item:
File | Description | Size | Format | |
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646925.pdf | 634.89 kB | Adobe PDF | View/Open |
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