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http://hdl.handle.net/2445/66415
Title: | Potential Role of Induced Pluripotent Stem Cells (IPSCs) for Cell-Based Therapy of the Ocular Surface |
Author: | Casaroli Marano, Ricardo Pedro Nieto-Nicolau, Nuria Martínez-Conesa, Eva M. Edel, Michael John Álvarez Palomo, Ana Belén |
Keywords: | Cèl·lules mare embrionàries Oftalmopaties Teràpia cel·lular Ull Embryonic stem cells Eye diseases Cellular therapy Eye |
Issue Date: | 12-Feb-2015 |
Publisher: | MDPI |
Abstract: | The integrity and normal function of the corneal epithelium are crucial for maintaining the cornea's transparency and vision. The existence of a cell population with progenitor characteristics in the limbus maintains a dynamic of constant epithelial repair and renewal. Currently, cell-based therapies for bio replacement cultured limbal epithelial transplantation (CLET) and cultured oral mucosal epithelial transplantation (COMET) present very encouraging clinical results for treating limbal stem cell deficiency (LSCD) and restoring vision. Another emerging therapeutic approach consists of obtaining and implementing human progenitor cells of different origins in association with tissue engineering methods. The development of cell-based therapies using stem cells, such as human adult mesenchymal or induced pluripotent stem cells (IPSCs), represent a significant breakthrough in the treatment of certain eye diseases, offering a more rational, less invasive, and better physiological treatment option in regenerative medicine for the ocular surface. This review will focus on the main concepts of cell-based therapies for the ocular surface and the future use of IPSCs to treat LSCD. |
Note: | Reproducció del document publicat a: http://dx.doi.org/10.3390/jcm4020318 |
It is part of: | Journal of Clinical Medicine, 2015, vol. 4, num. 2, p. 318-342 |
URI: | http://hdl.handle.net/2445/66415 |
Related resource: | http://dx.doi.org/10.3390/jcm4020318 |
ISSN: | 2077-0383 |
Appears in Collections: | Articles publicats en revistes (Ciències Fisiològiques) |
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