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Title: Biopharmaceutical profile of pranoprofen-loaded PLGA nanoparticles containing hydrogels for ocular administration
Author: Abrego Escobar, Guadalupe
Alvarado, Helen
Souto, Eliana B.
Guevara, Bessy
Halbaut, Lyda
Parra Coca, Alexander
Calpena Campmany, Ana Cristina
García López, María Luisa
Keywords: Antiinflamatoris no esteroïdals
Terapèutica oftalmològica
Administració de medicaments
Nonsteroidal anti-inflammatory agents
Ophthalmological therapeutics
Administration of drugs
Issue Date: 11-Feb-2015
Publisher: Elsevier B.V.
Abstract: Two optimized pranoprofen-loaded poly-L-lactic-co glycolic acid (PLGA) nanoparticles (PF-F1NPs; PF- 39 F2NPs) have been developed and further dispersed into hydrogels for the production of semi-solid formu- 40 lations intended for ocular administration. The optimized PF-NP suspensions were dispersed in freshly 41 prepared carbomer hydrogels (HG_PF-F1NPs and HG_PF-F2NPs) or in hydrogels containing 1% azone 42 (HG_PF-F1NPs-Azone and HG_PF-F2NPs-Azone) in order to improve the ocular biopharmaceutical profile 43 of the selected non-steroidal anti-inflammatory drug (NSAID), by prolonging the contact of the pranopro- 44 fen with the eye, increasing the drug retention in the organ and enhancing its anti-inflammatory and 45 analgesic efficiency. Carbomer 934 has been selected as gel-forming polymer. The hydrogel formulations 46 with or without azone showed a non-Newtonian behavior and adequate physicochemical properties for 47 ocular instillation. The release study of pranoprofen from the semi-solid formulations exhibited a sus- 48 tained release behavior. The results obtained from ex vivo corneal permeation and in vivo anti-inflamma- 49 tory efficacy studies suggest that the ocular application of the hydrogels containing azone was more 50 effective over the azone-free formulations in the treatment of edema on the ocular surface. No signs of 51 ocular irritancy have been detected for the produced hydrogels.
Note: Versió postprint del document publicat a:
It is part of: European Journal of Pharmaceutics and Biopharmaceutics, 2015
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ISSN: 0939-6411
Appears in Collections:Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)

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