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Title: An integrin-targeted photoactivatable Pt(IV) complex as a selective anticancer pro-drug: synthesis and photoactivation studies
Author: Gandioso, Albert
Shaili, Evyenia
Massaguer i Vall-llovera, Anna
Artigas Solé, Gerard
González-Cantó, Alejandro
Woods, Julie A.
Sadler, Peter
Marchán Sancho, Vicente
Keywords: Quimioteràpia del càncer
Cancer chemotherapy
Issue Date: 28-Apr-2015
Publisher: Royal Society of Chemistry
Abstract: A new anticancer agent based on the conjugation of a photoactivatable Pt(IV) pro-drug to a cyclic RGD-containing peptide is described. Upon visible light irradiation, phototoxicity was induced preferentially in SK-MEL-28 melanoma cancer cells overexpressing alphaVbeta3 integrin compared to control DU-145 human prostate carcinoma cells.
Note: Versió postprint del document publicat a:
It is part of: Chemical Communications, 2015, vol. 51, p. 9169-9172
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ISSN: 1359-7345
Appears in Collections:Articles publicats en revistes (Química Inorgànica i Orgànica)

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