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https://hdl.handle.net/2445/67182| Title: | An integrin-targeted photoactivatable Pt(IV) complex as a selective anticancer pro-drug: synthesis and photoactivation studies |
| Author: | Gandioso, Albert Shaili, Evyenia Massaguer i Vall-llovera, Anna Artigas Solé, Gerard González-Cantó, Alejandro Woods, Julie A. Sadler, Peter Marchán Sancho, Vicente |
| Keywords: | Quimioteràpia del càncer Cancer chemotherapy |
| Issue Date: | 28-Apr-2015 |
| Publisher: | Royal Society of Chemistry |
| Abstract: | A new anticancer agent based on the conjugation of a photoactivatable Pt(IV) pro-drug to a cyclic RGD-containing peptide is described. Upon visible light irradiation, phototoxicity was induced preferentially in SK-MEL-28 melanoma cancer cells overexpressing alphaVbeta3 integrin compared to control DU-145 human prostate carcinoma cells. |
| Note: | Versió postprint del document publicat a: http://dx.doi.org/10.1039/C5CC03180J |
| It is part of: | Chemical Communications, 2015, vol. 51, p. 9169-9172 |
| URI: | https://hdl.handle.net/2445/67182 |
| Related resource: | http://dx.doi.org/10.1039/C5CC03180J |
| ISSN: | 1359-7345 |
| Appears in Collections: | Articles publicats en revistes (Química Inorgànica i Orgànica) |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 651927.pdf | 303.76 kB | Adobe PDF | View/Open |
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