Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/67190
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Paris, Clément | - |
dc.contributor.author | Brun Cubero, Omar | - |
dc.contributor.author | Pedroso Muller, Enrique | - |
dc.contributor.author | Grandas Sagarra, Anna | - |
dc.date.accessioned | 2015-10-08T10:07:39Z | - |
dc.date.available | 2015-10-08T10:07:39Z | - |
dc.date.issued | 2015-04-10 | - |
dc.identifier.issn | 1420-3049 | - |
dc.identifier.uri | http://hdl.handle.net/2445/67190 | - |
dc.description.abstract | This manuscript reviews the possibilities offered by 2,5-dimethylfuran-protected maleimides. Suitably derivatized building blocks incorporating the exo Diels-Alder cycloadduct can be introduced at any position of oligonucleotides, peptide nucleic acids, peptides and peptoids, making use of standard solid-phase procedures. Maleimide deprotection takes place upon heating, which can be followed by either Michael-type or Diels-Alder click conjugation reactions. However, the one-pot procedure in which maleimide deprotection and conjugation are simultaneously carried out provides the target conjugate more quickly and, more importantly, in better yield. This procedure is compatible with conjugates involving oligonucleotides, peptides and peptide nucleic acids. A variety of cyclic peptides and oligonucleotides can be obtained from peptide and oligonucleotide precursors incorporating protected maleimides and thiols. | - |
dc.format.extent | 20 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/doi:10.3390/molecules20046389 | - |
dc.relation.ispartof | Molecules, 2015, vol. 20, p. 6389-6408 | - |
dc.relation.uri | http://dx.doi.org/doi:10.3390/molecules20046389 | - |
dc.rights | cc-by (c) Paris, Clément et al., 2015 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Química Inorgànica i Orgànica) | - |
dc.subject.classification | Pèptids | - |
dc.subject.classification | Oligonucleòtids | - |
dc.subject.classification | Àcids nucleics | - |
dc.subject.other | Peptides | - |
dc.subject.other | Oligonucleotides | - |
dc.subject.other | Nucleic acids | - |
dc.title | Exploiting protected maleimides to modify oligonucleotides, peptides and peptide nucleic acids | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 652078 | - |
dc.date.updated | 2015-10-08T10:07:39Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 25867825 | - |
Appears in Collections: | Articles publicats en revistes (Química Inorgànica i Orgànica) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
652078.pdf | 381.7 kB | Adobe PDF | View/Open |
This item is licensed under a
Creative Commons License