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Title: Ecto-nucleotidases activities in the contents of ovarian endometriomas: potential biomarkers of endometriosis
Author: Texidó, Laura
Romero, Claudia
Vidal-Bel, August
Garcia Valero, Josep
Fernández Montolí, Ma. Eulalia
Baixeras, Núria
Condom i Mundó, Enric
Ponce i Sebastià, Jordi
García-Tejedor, Amparo
Martín Satué, Mireia
Keywords: Endometriosi
Cysts (Pathology)
Issue Date: 3-Sep-2014
Publisher: Hindawi Publishing Corporation
Abstract: Endometriosis, defined as the growth of endometrial tissue outside the uterus, is a common gynecologic condition affecting millions of women worldwide. It is an inflammatory, estrogen-dependent complex disorder, with broad symptomatic variability, pelvic pain, and infertility being the main characteristics. Ovarian endometriomas are frequently developed in women with endometriosis. Late diagnosis is one of the main problems of endometriosis; thus, it is important to identify biomarkers for early diagnosis. The aim of the present work is to evaluate the ecto-nucleotidases activities in the contents of endometriomas. These enzymes, through the regulation of extracellular ATP and adenosine levels, are key enzymes in inflammatory processes, and their expression has been previously characterized in human endometrium. To achieve our objective, the echo-guided aspirated fluids of endometriomas were analyzed by evaluating the ecto-nucleotidases activities and compared with simple cysts. Our results show that enzyme activities are quantifiable in the ovarian cysts aspirates and that endometriomas show significantly higher ecto-nucleotidases activities than simple cysts (5.5-fold increase for ATPase and 20-fold for ADPase), thus being possible candidates for new endometriosis biomarkers. Moreover, we demonstrate the presence of ecto-nucleotidases bearing exosomes in these fluids. These results add up to the knowledge of the physiopathologic mechanisms underlying endometriosis and, open up a promising new field of study.
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It is part of: Mediators of Inflammation, 2014, vol. 2014, p. 1-8
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ISSN: 0962-9351
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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