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Title: | Superior antigen-specific CD4+ T-cell response with AS03-adjuvantation of a trivalent influenza vaccine in a randomised trial of adults aged 65 and older |
Author: | Couch, Robert B. Bayas Rodríguez, José María Caso, Covadonga Mbawuike, Innocent Nnadi Núñez López, Concepción Claeys, Carine El Idrissi, Mohamed Herve, Caroline Laupeze, Beatrice Oostvogels, Lidia Moris, Philippe |
Keywords: | Grip Vacunació Persones grans Assaigs clínics Influenza Vaccination Older people Clinical trials |
Issue Date: | 30-Jul-2014 |
Publisher: | BioMed Central |
Abstract: | BACKGROUND: The effectiveness of trivalent influenza vaccines may be reduced in older versus younger adults because of age-related immunosenescence. The use of an adjuvant in such a vaccine is one strategy that may combat immunosenescence, potentially by bolstering T-cell mediated responses. METHODS: This observer-blind study, conducted in the United States (US) and Spain during the 2008-2009 influenza season, evaluated the effect of Adjuvant System AS03 on specific T-cell responses to a seasonal trivalent influenza vaccine (TIV) in >/=65 year-old adults.Medically-stable adults aged >/=65 years were randomly allocated to receive a single dose of AS03-adjuvanted TIV (TIV/AS03) or TIV. Healthy adults aged 18-40 years received only TIV. Blood samples were collected on Day 0, Day 21, Day 42 and Day 180. Influenza-specific CD4+ T cells, defined by the induction of the immune markers CD40L, IL-2, IFN-gamma, or TNF-alpha, were measured in ex vivo cultures of antigen-stimulated peripheral blood mononuclear cells. RESULTS: A total of 192 adults were vaccinated: sixty nine and seventy three >/=65 year olds received TIV/AS03 and TIV, respectively; and fifty 18 - 40 year olds received TIV. In the >/=65 year-old group on Day 21, the frequency of CD4+ T cells specific to the three vaccine strains was superior in the TIV/AS03 recipients to the frequency in TIV (p < 0.001). On Days 42 and 180, the adjusted-geometric mean specific CD4+ T-cell frequencies were also higher in the TIV/AS03 recipients than in the TIV recipients (p < 0.001). Furthermore, the adjusted-geometric mean specific CD4+ T-cell frequencies were higher in the >/=65 year-old recipients of TIV/AS03 than in the 18 - 40 year old recipients of TIV on Days 21 (p = 0.006) and 42 (p = 0.011). CONCLUSION: This positive effect of AS03 Adjuvant System on the CD4+ T-cell response to influenza vaccine strains in older adults could confer benefit in protection against clinical influenza disease in this population. TRIAL REGISTRATION: (Clinicaltrials.gov.). NCT00765076. |
Note: | Reproducció del document publicat a: http://dx.doi.org/10.1186/1471-2334-14-425 |
It is part of: | BMC Infectious Diseases, 2014, num. 14, p. 425 |
URI: | http://hdl.handle.net/2445/68435 |
Related resource: | http://dx.doi.org/10.1186/1471-2334-14-425 |
ISSN: | 1471-2334 |
Appears in Collections: | Articles publicats en revistes (ISGlobal) |
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