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Title: Extracellular vesicles in parasitic diseases
Author: Marcilla, Antonio
Martín Jaular, Lorena
Trelis, Maria
Menezes Neto, Armando de
Osuna, Antonio
Bernal, Dolores
Fernández Becerra, María del Carmen
Almeida, Igor Correia de
Portillo Obando, Hernando A. del
Keywords: Malalties parasitàries
Salut pública
Parasitic diseases
Public health
Issue Date: 22-Dec-2014
Publisher: Co-Action Publishing
Abstract: Parasitic diseases affect billions of people and are considered a major public health issue. Close to 400 species are estimated to parasitize humans, of which around 90 are responsible for great clinical burden and mortality rates. Unfortunately, they are largely neglected as they are mainly endemic to poor regions. Of relevance to this review, there is accumulating evidence of the release of extracellular vesicles (EVs) in parasitic diseases, acting both in parasite-parasite inter-communication as well as in parasite-host interactions. EVs participate in the dissemination of the pathogen and play a role in the regulation of the host immune systems. Production of EVs from parasites or parasitized cells has been described for a number of parasitic infections. In this review, we provide the most relevant findings of the involvement of EVs in intercellular communication, modulation of immune responses, involvement in pathology, and their potential as new diagnostic tools and therapeutic agents in some of the major human parasitic pathogens.
Note: Reproducció del document publicat a:
It is part of: Journal of Extracellular Vesicles, 2014, núm. 3, p. 25040
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ISSN: 2001-3078
Appears in Collections:Articles publicats en revistes (ISGlobal)

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