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http://hdl.handle.net/2445/7602
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DC Field | Value | Language |
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dc.contributor.author | Grau, Juan José | cat |
dc.contributor.author | Palmero, Ramón | cat |
dc.contributor.author | Marmol, Maribel | cat |
dc.contributor.author | Domingo Domènech, Josep Maria | cat |
dc.contributor.author | Monzó Planella, Mariano | cat |
dc.contributor.author | Fuster Obregón, Josep | cat |
dc.contributor.author | Vidal, Oscar | cat |
dc.contributor.author | Fondevila Campo, Constantino | cat |
dc.contributor.author | García-Valdecasas Salgado, Juan Carlos | cat |
dc.date.accessioned | 2009-04-03T13:35:09Z | - |
dc.date.available | 2009-04-03T13:35:09Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 1477-7819 | - |
dc.identifier.uri | http://hdl.handle.net/2445/7602 | - |
dc.description.abstract | Background: We investigated the change of prognosis in resected gastric cancer (RGC) patients and the role of radical surgery and adjuvant chemotherapy. Methods: We retrospectively analyze the outcome of 426 consecutive patients from 1975 to 2002, divided into 2 time-periods (TP) cohort: Before 1990 (TP1, n = 207) and 1990 or after (TP2; n= 219). Partial gastrectomy and D1-lymphadenetomy was predominant in TP1 and total gastrectomy with D2-lymphadenectomy it was in TP2. Adjuvant chemotherapy consisted of mitomycin C (MMC), 10¿20 mg/m2 iv 4 courses or MMC plus Tegafur 500 mg/m2 for 6 months. Results: Positive nodes were similar in TP2/TP1 patients with 56%/59% respectively. Total gastrectomy was done in 56%/45% of TP2/TP1 respectively. Two-drug adjuvant chemotherapy was administered in 65%/18% of TP2/TP1 respectively. Survival at 5 years was 66% for TP2 versus 42% for TP1 patients (p < 0.0001). Survival by stages II, IIIA y IIIB for TP2 versus TP1 patients was 70 vs. 51% (p = 0.0132); 57 vs. 22% (p = 0.0008) y 30 vs. 15% (p = 0.2315) respectively. Multivariate analysis showed that age, stage of disease and period of treatment were independent variables. Conclusion: The global prognosis and that of some stages have improved in recent years with case RGC patients treated with surgery and adjuvant chemotherapy. | eng |
dc.format.extent | 9 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | eng |
dc.publisher | BioMed Central | cat |
dc.relation.isformatof | Reproducció del document publicat a http://dx.doi.org/10.1186/1477-7819-4-53 | cat |
dc.relation.ispartof | World Journal of Surgical Oncology, 2006, vol. 4, núm. 53 | cat |
dc.relation.uri | http://dx.doi.org/10.1186/1477-7819-4-53 | - |
dc.rights | cc-by, (c) Grau et al., 2006 | cat |
dc.rights.uri | http://creativecommons.org/licenses/by/2.0/ | eng |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Aparell digestiu | cat |
dc.subject.classification | Càncer | cat |
dc.subject.classification | Quimioteràpia | cat |
dc.subject.other | Gastric cancer | eng |
dc.subject.other | Chemotherapy | eng |
dc.title | Time-related improvement of survival in resectable gastric cancer: the role of Japanese-style gastrectomy with D2 lymphadenectomy and adjuvant chemotherapy | eng |
dc.type | info:eu-repo/semantics/article | eng |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 543027 | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 16904003 | - |
Appears in Collections: | Articles publicats en revistes (Medicina) |
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