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DC Field | Value | Language |
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dc.contributor.author | Vidal Taboada, José Manuel | cat |
dc.contributor.author | Cucala, Mercedes | cat |
dc.contributor.author | Mas Herrero, Sergi | cat |
dc.contributor.author | Lafuente, Amàlia, 1952-2022 | cat |
dc.contributor.author | Cobos Carbó, Albert | cat |
dc.date.accessioned | 2009-05-07T08:26:47Z | - |
dc.date.available | 2009-05-07T08:26:47Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 1471-2350 | - |
dc.identifier.uri | http://hdl.handle.net/2445/8042 | - |
dc.description.abstract | Background: Pharmacogenetic studies are essential in understanding the interindividual variability of drug responses. DNA sample collection for genotyping is a critical step in genetic studies. A method using dried blood samples from finger-puncture, collected on DNA-cards, has been described as an alternative to the usual venepuncture technique. The purpose of this study is to evaluate the implementation of the DNA cards method in a multicentre clinical trial, and to assess the degree of investigators' satisfaction and the acceptance of the patients perceived by the investigators.Methods: Blood samples were collected on DNA-cards. The quality and quantity of DNA recovered were analyzed. Investigators were questioned regarding their general interest, previous experience, safety issues, preferences and perceived patient satisfaction. Results: 151 patients' blood samples were collected. Genotyping of GST polymorphisms was achieved in all samples (100%). 28 investigators completed the survey. Investigators perceived patient satisfaction as very good (60.7%) or good (39.3%), without reluctance to finger puncture. Investigators preferred this method, which was considered safer and better than the usual methods. All investigators would recommend using it in future genetic studies. Conclusion: Within the clinical trial setting, the DNA-cards method was very well accepted by investigators and patients (in perception of investigators), and was preferred to conventional methods due to its ease of use and safety. | eng |
dc.format.extent | 9 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | eng |
dc.publisher | BioMed Central | cat |
dc.relation.isformatof | Reproducció del document publicat a http://dx.doi.org/10.1186/1471-2350-7-45 | cat |
dc.relation.ispartof | BMC Medical Genetics, 2006, vol. 7, núm. 45 | cat |
dc.relation.uri | http://dx.doi.org/10.1186/1471-2350-7-45 | - |
dc.rights | cc-by, (c) Vidal-Taboada et al., 2006 | cat |
dc.rights.uri | http://creativecommons.org/licenses/by/2.0/ | cat |
dc.source | Articles publicats en revistes (Fonaments Clínics) | - |
dc.subject.classification | ADN | cat |
dc.subject.classification | Sang | cat |
dc.subject.classification | Farmacogenètica | cat |
dc.subject.classification | Investigació farmacèutica | cat |
dc.subject.other | DNA analysis | eng |
dc.subject.other | Blood | eng |
dc.subject.other | Glutathione transferase | eng |
dc.title | Satisfaction survey with DNA cards method to collect genetic samples for pharmacogenetics studies | eng |
dc.type | info:eu-repo/semantics/article | eng |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 543202 | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 16681846 | - |
Appears in Collections: | Articles publicats en revistes (Fonaments Clínics) |
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543202.pdf | 473.45 kB | Adobe PDF | View/Open |
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