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DC Field | Value | Language |
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dc.contributor.author | Rodríguez-Roisin, Robert | cat |
dc.contributor.author | Félez Flor, Miguel Ángel | cat |
dc.contributor.author | Chung, K. Fan, 1951- | cat |
dc.contributor.author | Barberà i Mir, Joan Albert | cat |
dc.contributor.author | Wagner, P. D. (Peter D.) | cat |
dc.contributor.author | Cobos Carbó, Albert | cat |
dc.contributor.author | Barnes, Peter J. | cat |
dc.contributor.author | Roca Torrent, Josep | cat |
dc.date.accessioned | 2009-05-14T10:11:52Z | - |
dc.date.available | 2009-05-14T10:11:52Z | - |
dc.date.issued | 1994 | cat |
dc.identifier.issn | 0021-9738 | cat |
dc.identifier.uri | http://hdl.handle.net/2445/8262 | - |
dc.description.abstract | We hypothesized that platelet-activating factor (PAF), a potent inflammatory mediator, could induce gas exchange abnormalities in normal humans. To this end, the effect of aerosolized PAF (2 mg/ml solution; 24 micrograms) on ventilation-perfusion (VA/Q) relationships, hemodynamics, and resistance of the respiratory system was studied in 14 healthy, nonatopic, and nonsmoking individuals (23 +/- 1 [SEM]yr) before and at 2, 4, 6, 8, 15, and 45 min after inhalation, and compared to that of inhaled lyso-PAF in 10 other healthy individuals (24 +/- 2 yr). PAF induced, compared to lyso-PAF, immediate leukopenia (P < 0.001) followed by a rebound leukocytosis (P < 0.002), increased minute ventilation (P < 0.05) and resistance of the respiratory system (P < 0.01), and decreased systemic arterial pressure (P < 0.05). Similarly, compared to lyso-PAF, PaO2 showed a trend to fall (by 12.2 +/- 4.3 mmHg, mean +/- SEM maximum change from baseline), and arterial-alveolar O2 gradient increased (by 16.7 +/- 4.3 mmHg) (P < 0.02) after PAF, because of VA/Q mismatch: the dispersion of pulmonary blood flow and that of ventilation increased by 0.45 +/- 0.1 (P < 0.01) and 0.29 +/- 0.1 (P < 0.04), respectively. We conclude that in normal subjects, inhaled PAF results in considerable immediate VA/Q inequality and gas exchange impairment. These results reinforce the notion that PAF may play a major role as a mediator of inflammation in the human lung. | eng |
dc.format.extent | 7 p. | cat |
dc.format.mimetype | application/pdf | eng |
dc.language.iso | eng | eng |
dc.publisher | American Society for Clinical Investigation | cat |
dc.relation.isformatof | Reproducció del document publicat a http://dx.doi.org/10.1172/JCI116944 | cat |
dc.relation.ispartof | The Journal of Clinical Investigation, 1994, vol. 93, núm. 1, p. 188-194. | cat |
dc.relation.uri | http://dx.doi.org/10.1172/JCI116944 | - |
dc.rights | (c) The American Society for Clinical Investigation, 1994 | cat |
dc.source | Articles publicats en revistes (Biomedicina) | - |
dc.subject.classification | Asma | cat |
dc.subject.classification | Respiració | cat |
dc.subject.classification | Factor d'activació plaquetari | cat |
dc.subject.other | Pulmonary gas exchange | eng |
dc.subject.other | Asthma | eng |
dc.title | Platelet-activating factor causes ventilation-perfusion mismatch in humans | eng |
dc.type | info:eu-repo/semantics/article | eng |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 527894 | cat |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 8282786 | - |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (Biomedicina) |
Files in This Item:
File | Description | Size | Format | |
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527894.pdf | 1.63 MB | Adobe PDF | View/Open |
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