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DC Field | Value | Language |
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dc.contributor.author | Costelli, Paola | cat |
dc.contributor.author | Carbó Carbó, Neus | cat |
dc.contributor.author | Tessitore, Luciana | cat |
dc.contributor.author | Bagby, Gregory J. | cat |
dc.contributor.author | López-Soriano, Francisco J. | cat |
dc.contributor.author | Argilés Huguet, Josep Ma. | cat |
dc.contributor.author | Baccino, Francesco M. | cat |
dc.date.accessioned | 2009-05-14T10:14:17Z | - |
dc.date.available | 2009-05-14T10:14:17Z | - |
dc.date.issued | 1993 | cat |
dc.identifier.issn | 0021-9738 | cat |
dc.identifier.uri | http://hdl.handle.net/2445/8263 | - |
dc.description.abstract | Rats bearing the Yoshida AH-130 ascites hepatoma showed enhanced fractional rates of protein degradation in gastrocnemius muscle, heart, and liver, while fractional synthesis rates were similar to those in non-tumor bearing rats. This hypercatabolic pattern was associated with marked perturbations of the hormonal homeostasis and presence of tumor necrosis factor in the circulation. The daily administration of a goat anti-murine TNF IgG to tumor-bearing rats decreased protein degradation rates in skeletal muscle, heart, and liver as compared with tumor-bearing rats receiving a nonimmune goat IgG. The anti-TNF treatment was also effective in attenuating early perturbations in insulin and corticosterone homeostasis. Although these results suggest that tumor necrosis factor plays a significant role in mediating the changes in protein turnover and hormone levels elicited by tumor growth, the inability of such treatment to prevent a reduction in body weight implies that other mediators or tumor-related events were also involved. | eng |
dc.format.extent | 7 p. | cat |
dc.format.mimetype | application/pdf | eng |
dc.language.iso | eng | eng |
dc.publisher | American Society for Clinical Investigation | cat |
dc.relation.isformatof | Reproducció del document publicat a http://dx.doi.org/doi:10.1172/JCI116897 | cat |
dc.relation.ispartof | Journal of Clinical Investigation, 1993, vol. 92, núm. 6, p. 2783-2789. | cat |
dc.rights | (c) The American Society for Clinical Investigation, 1993 | cat |
dc.source | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) | - |
dc.subject.classification | Tumors | cat |
dc.subject.classification | Necrosi | cat |
dc.subject.classification | Músculs | cat |
dc.subject.other | Tumor necrosis factor | eng |
dc.subject.other | Skeletal muscle | eng |
dc.subject.other | Protein turnover | eng |
dc.title | Tumor necrosis factor-alpha mediates changes in tissue protein turnover in a rat cancer cachexia model. | eng |
dc.type | info:eu-repo/semantics/article | eng |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 79740 | cat |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 8254032 | - |
Appears in Collections: | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) |
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