Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/96085
Title: | Biological convergence of cancer signatures |
Author: | Solé Acha, Xavier Bonifaci Cano, Núria López Bigas, Núria Berenguer, Antoni Hernández, Pilar Reina, Oscar Maxwell, Christopher A. Aguilar, Helena Urruticoechea Ribate, Ander Sanjosé Llongueras, Silvia de Comellas, Francesc Capellá, G. (Gabriel) Moreno Aguado, Víctor Pujana Genestar, M. Ángel |
Keywords: | Càncer Expressió gènica Mort cel·lular Metàstasi Cancer Gene expression Cell death Metastasis |
Issue Date: | 20-Feb-2009 |
Publisher: | Public Library of Science (PLoS) |
Abstract: | Gene expression profiling has identified cancer prognostic and predictive signatures with superior performance to conventional histopathological or clinical parameters. Consequently, signatures are being incorporated into clinical practice and will soon influence everyday decisions in oncology. However, the slight overlap in the gene identity between signatures for the same cancer type or condition raises questions about their biological and clinical implications. To clarify these issues, better understanding of the molecular properties and possible interactions underlying apparently dissimilar signatures is needed. Here, we evaluated whether the signatures of 24 independent studies are related at the genome, transcriptome or proteome levels. Significant associations were consistently observed across these molecular layers, which suggest the existence of a common cancer cell phenotype. Convergence on cell proliferation and death supports the pivotal involvement of these processes in prognosis, metastasis and treatment response. In addition, functional and molecular associations were identified with the immune response in different cancer types and conditions that complement the contribution of cell proliferation and death. Examination of additional, independent, cancer datasets corroborated our observations. This study proposes a comprehensive strategy for interpreting cancer signatures that reveals common design principles and systems-level properties. |
Note: | Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0004544 |
It is part of: | PLoS One, 2009, vol. 4, num. 2, p. e4544 |
URI: | http://hdl.handle.net/2445/96085 |
Related resource: | http://dx.doi.org/10.1371/journal.pone.0004544 |
ISSN: | 1932-6203 |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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