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Title: New cationic vesicles prepared with double chain surfactants from arginine: role of the hydrophobic group on the antimicrobial activity and cytotoxicity
Author: Pinazo Gassol, Aurora
Petrizelli, V.
Bustelo, M.
Pons Pons, Ramon
Vinardell Martínez-Hidalgo, Ma. Pilar
Mitjans Arnal, Montserrat
Manresa Presas, Ma. Ángeles (María Ángeles)
Pérez Muñoz, Lourdes
Keywords: Aminoàcids
Agents tensioactius
Microbiologia farmacèutica
Amino acids
Surface active agents
Pharmaceutical microbiology
Issue Date: 1-May-2016
Publisher: Elsevier B.V.
Abstract: Cationic double chain surfactants have attracted much interest because they can give rise to cationic vesicles that can be used in biomedical applications. Using a simple and economical synthetic approach, we have synthesized four double-chain surfactants with different alkyl chain lengths (LANHCx). The critical aggregation concentration of the double chain surfactants is at least one order of magnitude lower than the CMC of their corresponding single-chain LAM and the solutions prepared with the LANHCx contain stable cationic vesicles. Encouragingly, these new arginine derivatives show very low haemolytic activity and weaker cytotoxic effects than conventional dialkyl dimethyl ammonium surfactants. In addition, the surfactant with the shortest alkyl chain exhibits good antimicrobial activity against Gram-positive bacteria. The results show that a rational design applied to cationic double chain surfactants might serve as a promising strategy for the development of safe cationic vesicular systems.
Note: Versió postprint del document publicat a:
It is part of: Colloids and Surfaces B-Biointerfaces, 2016, vol. 141, p. 19-27
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ISSN: 0927-7765
Appears in Collections:Articles publicats en revistes (Bioquímica i Fisiologia)
Articles publicats en revistes (Biologia, Sanitat i Medi Ambient)

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