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Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/97493
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dc.contributor.authorDituri, Francesco-
dc.contributor.authorMazzocca, Antonio-
dc.contributor.authorPeidrò, Fernando Juan-
dc.contributor.authorPapappicco, Patrizia-
dc.contributor.authorFabregat Romero, Isabel-
dc.contributor.authorDe Santis, Flavia-
dc.contributor.authorParadiso, Angelo-
dc.contributor.authorSabbà, Carlo-
dc.contributor.authorGiannelli, Gianluigi-
dc.date.accessioned2016-04-15T13:57:06Z-
dc.date.available2016-04-15T13:57:06Z-
dc.date.issued2013-
dc.identifier.issn1932-6203-
dc.identifier.urihttp://hdl.handle.net/2445/97493-
dc.description.abstractWe investigated blocking the TGF-b signaling pathway in HCC using two small molecule inhibitors (LY2157299, LY2109761) and a neutralizing humanized antibody (D10) against TGF-bRII. LY2157299 and LY2109761 inhibited HCC cell migration on Laminin-5, Fibronectin, Vitronectin, Fibrinogen and Collagen-I and de novo phosphorylation of pSMAD2. LY2157299 inhibited HCC migration and cell growth independently of the expression levels of TGF-bRII. In contrast to LY2157299, D10 showed a reduction in pSMAD2 only after a short exposure. This study supports the use of LY2157299 in clinical trials, and presents new insights into TGF-b receptor cycling in cancer cells.-
dc.format.extent15 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherPublic Library of Science (PLoS)-
dc.relation.isformatofReproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0067109-
dc.relation.ispartofPLoS One, 2013, vol. 8, num. 6, p. e67109-
dc.relation.urihttp://dx.doi.org/10.1371/journal.pone.0067109-
dc.rightscc-by (c) Dituri, Francesco et al., 2013-
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es-
dc.sourceArticles publicats en revistes (Ciències Fisiològiques)-
dc.subject.classificationAnticossos monoclonals-
dc.subject.classificationFosforilació-
dc.subject.classificationCàncer de fetge-
dc.subject.classificationFactors de creixement-
dc.subject.otherMonoclonal antibodies-
dc.subject.otherPhosphorylation-
dc.subject.otherLiver cancer-
dc.subject.otherGrowth factors-
dc.titleDifferential inhibition of the TGF-b signaling pathway in HCC cells using the small molecule inhibitor LY2157299 and the D10 monoclonal antibody against TGF-β receptor Type II-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.identifier.idgrec639728-
dc.date.updated2016-04-15T13:57:12Z-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
dc.identifier.pmid23826206-
Appears in Collections:Articles publicats en revistes (Ciències Fisiològiques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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