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http://hdl.handle.net/2445/97646
Title: | Role of the tissue microenvironment as a therapeutic target in hepatocellular carcinoma |
Author: | Bhavna, Rani Cao, Yuan Malfettone, Andrea Tomuleasa, Ciprian Fabregat Romero, Isabel Giannelli, Gianluigi |
Keywords: | Carcinogènesi Factors de creixement Cèl·lules canceroses Carcinogenesis Growth factors Cancer cells |
Issue Date: | 2014 |
Publisher: | Baishideng Publishing Group |
Abstract: | Hepatocellular carcinoma is difficult to treat, primarily because the underlying molecular mechanisms driving clinical outcome are still poorly understood. Growing evidence suggests that the tissue microenvironment has a role in the biological behavior of the tumor. The main clinical issue is to identify the best target for therapeutic approaches. Here, we discuss the hypothesis that the entire tissue microenvironment might be considered as a biological target. However, the tissue microenvironment consists of several cellular and biochemical components, each of which displays a distinct biological activity. We discuss the major components of this environment and consider how they may interact to promote tumor/host crosstalk. |
Note: | Reproducció del document publicat a: http://dx.doi.org/10.3748/wjg.v20.i15.4128 |
It is part of: | World Journal of Gastroenterology, 2014, vol. 20, num. 15, p. 4128-4140 |
URI: | http://hdl.handle.net/2445/97646 |
Related resource: | http://dx.doi.org/10.3748/wjg.v20.i15.4128 |
ISSN: | 1007-9327 |
Appears in Collections: | Articles publicats en revistes (Ciències Fisiològiques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Publicacions de projectes de recerca finançats per la UE |
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