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Title: | Synthesis of (E)-4-bromo-3-methoxybut-3-en-2-one, the key fragment in the polyhydroxylated chain common to oscillariolide and phormidolides A-C |
Author: | Gil, Alejandro Lamariano Merketegi, Janire Lorente Crivillé, Adriana Albericio Palomera, Fernando Álvarez Domingo, Mercedes |
Keywords: | Productes naturals Síntesi asimètrica Química orgànica Natural products Asymmetric synthesis Organic chemistry |
Issue Date: | 17-May-2016 |
Publisher: | Wiley-VCH |
Abstract: | The terminal bromomethoxydiene (BMD) moiety of the polyhydroxylated chain present in phormidolides and oscillariolides has been synthesized for first time. Several strategies for the stereoselective synthesis of the 4-bromo-3-methoxybut-3-en-2-ones are described. Furthermore, a preliminary study to successfully introduce this fragment within the polyol chain and introduction of the fatty acid allowed corroborate the end structure of the polyol. |
Note: | Versió postprint del document publicat a: http://dx.doi.org/10.1002/chem.201600770 |
It is part of: | Chemistry-A European Journal, 2016, vol. 22, num. 21, p. 7033-7035 |
URI: | http://hdl.handle.net/2445/98695 |
Related resource: | http://dx.doi.org/10.1002/chem.201600770 |
ISSN: | 0947-6539 |
Appears in Collections: | Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) Articles publicats en revistes (Química Inorgànica i Orgànica) |
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