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Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/98971
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dc.contributor.authorGuignard, Guillaume Michel Pablo-
dc.contributor.authorLlor Brunés, Núria-
dc.contributor.authorUrbina Teixidor, Aina-
dc.contributor.authorBosch Cartes, Joan-
dc.contributor.authorAmat Tusón, Mercedes-
dc.date.accessioned2016-05-27T16:03:53Z-
dc.date.available2017-03-01T23:01:19Z-
dc.date.issued2016-02-
dc.identifier.issn1434-193X-
dc.identifier.urihttp://hdl.handle.net/2445/98971-
dc.description.abstractA variety of (R)-phenylglycinol-derived oxazolopiperidone lactams 1-14 were converted to linear-chain enantiopure amino diols 15-26 by reduction with LiNH2BH3 in an unprecedented process involving the simultaneous reductive opening of the oxazolidine and lactam rings. Subsequent removal of the phenylethanol moiety gave enantiopure 5-amino-1-pentanols bearing substituents at the 2-, 3-, 4-, 2,2-, 2,3- 2,4- and 3,4-positions (28-36), which were isolated as their N-Boc derivatives.-
dc.format.extent11 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherWiley-VCH-
dc.relation.isformatofVersió postprint del document publicat a: http://dx.doi.org/10.1002/ejoc.201501409-
dc.relation.ispartofEuropean Journal of Organic Chemistry, 2016, vol. 2016, num. 4, p. 693-703-
dc.relation.urihttp://dx.doi.org/10.1002/ejoc.201501409-
dc.rights(c) Wiley-VCH, 2016-
dc.sourceArticles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)-
dc.subject.classificationSíntesi orgànica-
dc.subject.classificationSíntesi asimètrica-
dc.subject.classificationReducció química-
dc.subject.classificationLactames-
dc.subject.otherOrganic synthesis-
dc.subject.otherAsymmetric synthesis-
dc.subject.otherReduction (Chemistry)-
dc.subject.otherLactams-
dc.titleA general method for the synthesis of enantiopure 1,5-amino alcohols-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/acceptedVersion-
dc.identifier.idgrec659329-
dc.date.updated2016-05-27T16:03:58Z-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
Appears in Collections:Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
Articles publicats en revistes (Institut de Biomedicina (IBUB))

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