Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/99123
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Prat Aparicio, Aleix | - |
dc.contributor.author | Adamo, Barbara | - |
dc.contributor.author | Fan, Cheng | - |
dc.contributor.author | Peg, Vicente | - |
dc.contributor.author | Vidal Losada, Maria Jesús | - |
dc.contributor.author | Galván, Patricia | - |
dc.contributor.author | Vivancos, Ana | - |
dc.contributor.author | Nuciforo, Paolo | - |
dc.contributor.author | Palmer, Héctor G. | - |
dc.contributor.author | Dawood, Shaheenah | - |
dc.contributor.author | Rodón, Jordi | - |
dc.contributor.author | Ramón y Cajal Agüeras, Santiago | - |
dc.contributor.author | Campo, Josep Maria | - |
dc.contributor.author | Felip, Enriqueta | - |
dc.contributor.author | Tabernero Caturla, Josep | - |
dc.contributor.author | Cortés, Javier | - |
dc.date.accessioned | 2016-06-01T09:18:19Z | - |
dc.date.available | 2016-06-01T09:18:19Z | - |
dc.date.issued | 2013-12-18 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/2445/99123 | - |
dc.description.abstract | To improve our understanding of the biological relationships among different types of cancer, we have characterized variation in gene expression patterns in a set of 1,707 samples representing 6 human cancer types (breast, ovarian, brain, colorectal, lung adenocarcinoma and squamous cell lung cancer). In the unified dataset, breast tumors of the Basal-like subtype were found to represent a unique molecular entity as any other cancer type, including the rest of breast tumors, while showing striking similarities with squamous cell lung cancers. Moreover, gene signatures tracking various cancer- and stromal-related biological processes such as proliferation, hypoxia and immune activation were found expressed similarly in different proportions of tumors across the various cancer types. These data suggest that clinical trials focusing on tumors with common profiles and/or biomarker expression rather than their tissue of origin are warranted with a special focus on Basal-like breast cancer and squamous cell lung carcinoma. | - |
dc.format.extent | 13 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.1038/srep03544 | - |
dc.relation.ispartof | Scientific Reports, 2013, vol. 3, num. 3544 | - |
dc.relation.uri | http://dx.doi.org/10.1038/srep03544 | - |
dc.rights | cc-by-nc-nd (c) Prat Aparicio, Aleix et al., 2013 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Genòmica | - |
dc.subject.classification | Càncer | - |
dc.subject.classification | Marcadors bioquímics | - |
dc.subject.classification | Assaigs clínics | - |
dc.subject.classification | Oncologia | - |
dc.subject.other | Genomics | - |
dc.subject.other | Cancer | - |
dc.subject.other | Biochemical markers | - |
dc.subject.other | Clinical trials | - |
dc.subject.other | Oncology | - |
dc.title | Genomic Analyses across Six Cancer Types Identify Basal-like Breast Cancer as a Unique Molecular Entity | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 662497 | - |
dc.date.updated | 2016-06-01T09:18:25Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 24384914 | - |
Appears in Collections: | Articles publicats en revistes (Medicina) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
662497.pdf | 6.98 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License