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http://hdl.handle.net/2445/99260
Title: | Malaria Parasites in the Asymptomatic: Looking for the Hay in the Haystack |
Author: | Galatas, Beatriz Bassat Orellana, Quique Mayor Aparicio, Alfredo Gabriel |
Keywords: | Malària Malalties parasitàries Malaria Parasitic diseases |
Issue Date: | 19-Dec-2015 |
Publisher: | Elsevier Inc. |
Abstract: | With malaria elimination back on the international agenda, programs face the challenge of targeting all Plasmodium infections, not only symptomatic cases. As asymptomatic individuals are unlikely to seek treatment, they are missed by passive surveillance while remaining infectious to mosquitoes, thus acting as silent reservoirs of transmission. To estimate the risk of asymptomatic infections in various phases of malaria elimination, we need a deeper understanding of the underlying mechanisms favoring carriage over disease, which may involve both pathogen and host factors. Here we review our current knowledge on the determinants leading to Plasmodium falciparum symptomless infections. Understanding the host-pathogen interactions that are most likely to affect transitions between malaria disease states could guide the development of tools to tackle asymptomatic carriers in elimination settings. |
Note: | Reproducció del document publicat a: http://dx.doi.org/10.1016/j.pt.2015.11.015 |
It is part of: | Trends in Parasitology, 2016, vol. 32 , num. 4, p. 296-308 |
URI: | http://hdl.handle.net/2445/99260 |
Related resource: | http://dx.doi.org/10.1016/j.pt.2015.11.015 |
ISSN: | 1471-4922 |
Appears in Collections: | Articles publicats en revistes (ISGlobal) |
Files in This Item:
File | Description | Size | Format | |
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PIIS1471492215002597.pdf | 2.14 MB | Adobe PDF | View/Open |
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