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DC Field | Value | Language |
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dc.contributor.author | Sow, Samba O. | - |
dc.contributor.author | Muhsen, Khitam | - |
dc.contributor.author | Nasrin, Dilruba | - |
dc.contributor.author | Blackwelder, William C. | - |
dc.contributor.author | Wu, Yukun | - |
dc.contributor.author | Farag, Tamer H. | - |
dc.contributor.author | Panchalingam, Sandra | - |
dc.contributor.author | Sur, Dipika | - |
dc.contributor.author | Zaidi, Anita K. M. | - |
dc.contributor.author | Faruque, Abu S. G. | - |
dc.contributor.author | Saha, Debasish | - |
dc.contributor.author | Adegbola, Richard | - |
dc.contributor.author | Alonso, Pedro | - |
dc.contributor.author | Breiman, Robert F. | - |
dc.contributor.author | Bassat Orellana, Quique | - |
dc.contributor.author | Tamboura, Boubou | - |
dc.contributor.author | Sanogo, Doh | - |
dc.contributor.author | Onwuchekwa, Uma | - |
dc.contributor.author | Manna, Byomkesh | - |
dc.contributor.author | Ramamurthy, Thandavarayan | - |
dc.contributor.author | Kanungo, Suman | - |
dc.contributor.author | Ahmed, Shahnawaz | - |
dc.contributor.author | Qureshi, Shahida | - |
dc.contributor.author | Quadri, Farheen | - |
dc.contributor.author | Hossain, Anowar | - |
dc.contributor.author | Das, Sumon K. | - |
dc.contributor.author | Antonio, Martin | - |
dc.contributor.author | Hossain, M. Jahangir | - |
dc.contributor.author | Mandomando, Inácio | - |
dc.contributor.author | Nhampossa, Tacilta | - |
dc.contributor.author | Acácio, Sozinho | - |
dc.contributor.author | Omore, Richard | - |
dc.contributor.author | Oundo, Joseph O. | - |
dc.contributor.author | Ochieng, John B. | - |
dc.contributor.author | O'Reilly, Ciara E. | - |
dc.contributor.author | Berkeley, Lynette Y. | - |
dc.contributor.author | Livio, Sofie | - |
dc.contributor.author | Tennant, Sharon M. | - |
dc.contributor.author | Sommerfelt, Halvor | - |
dc.contributor.author | Nataro, James P. | - |
dc.contributor.author | Ziv-Baran, Tomer | - |
dc.contributor.author | Robins-Browne, Roy M. | - |
dc.contributor.author | Mishcherkin, Vladimir | - |
dc.contributor.author | Zhang, Jixian | - |
dc.contributor.author | Liu, Jie | - |
dc.contributor.author | Houpt, Eric R. | - |
dc.contributor.author | Kotloff, Karen L. | - |
dc.contributor.author | Levine, Myron M. | - |
dc.contributor.author | Mintz, Eric D. | - |
dc.date.accessioned | 2016-06-21T07:55:13Z | - |
dc.date.available | 2016-06-21T07:55:13Z | - |
dc.date.issued | 2016-05-24 | - |
dc.identifier.issn | 1935-2735 | - |
dc.identifier.uri | http://hdl.handle.net/2445/99682 | - |
dc.description.abstract | Background: The importance of Cryptosporidium as a pediatric enteropathogen in developing countries is recognized. Methods: Data from the Global Enteric Multicenter Study (GEMS), a 3-year, 7-site, case-control study of moderate-to-severe diarrhea (MSD) and GEMS-1A (1-year study of MSD and less-severe diarrhea [LSD]) were analyzed. Stools from 12,110 MSD and 3,174 LSD cases among children aged <60 months and from 21,527 randomly-selected controls matched by age, sex and community were immunoassay-tested for Cryptosporidium. Species of a subset of Cryptosporidium-positive specimens were identified by PCR; GP60 sequencing identified anthroponotic C. parvum. Combined annual Cryptosporidium-attributable diarrhea incidences among children aged <24 months for African and Asian GEMS sites were extrapolated to sub-Saharan Africa and South Asian regions to estimate region-wide MSD and LSD burdens. Attributable and excess mortality due to Cryptosporidium diarrhea were estimated. Findings: Cryptosporidium was significantly associated with MSD and LSD below age 24 months. Among Cryptosporidium-positive MSD cases, C. hominis was detected in 77.8% (95% CI, 73.0%-81.9%) and C. parvum in 9.9% (95% CI, 7.1%-13.6%); 92% of C. parvum tested were anthroponotic genotypes. Annual Cryptosporidium-attributable MSD incidence was 3.48 (95% CI, 2.27–4.67) and 3.18 (95% CI, 1.85–4.52) per 100 child-years in African and Asian infants, respectively, and 1.41 (95% CI, 0.73–2.08) and 1.36 (95% CI, 0.66–2.05) per 100 child-years in toddlers. Corresponding Cryptosporidium-attributable LSD incidences per 100 child-years were 2.52 (95% CI, 0.33–5.01) and 4.88 (95% CI, 0.82–8.92) in infants and 4.04 (95% CI, 0.56–7.51) and 4.71 (95% CI, 0.24–9.18) in toddlers. We estimate 2.9 and 4.7 million Cryptosporidium-attributable cases annually in children aged <24 months in the sub-Saharan Africa and India/Pakistan/Bangladesh/Nepal/Afghanistan regions, respectively, and ~202,000 Cryptosporidium-attributable deaths (regions combined). ~59,000 excess deaths occurred among Cryptosporidium-attributable diarrhea cases over expected if cases had been Cryptosporidium-negative. Conclusions: The enormous African/Asian Cryptosporidium disease burden warrants investments to develop vaccines, diagnostics and therapies. | - |
dc.format.extent | 20 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pntd.0004729 | - |
dc.relation.ispartof | PLoS Neglected Tropical Diseases, 2016, vol. 10, num. 5, p. e0004729 | - |
dc.relation.uri | http://dx.doi.org/10.1371/journal.pntd.0004729 | - |
dc.rights | cc0 (c) Sow et al., 2016 | - |
dc.rights.uri | http://creativecommons.org/publicdomain/zero/1.0/ | - |
dc.source | Articles publicats en revistes (ISGlobal) | - |
dc.subject.classification | Diarrea | - |
dc.subject.classification | Infants | - |
dc.subject.other | Diarrhea | - |
dc.subject.other | Children | - |
dc.title | The Burden of Cryptosporidium Diarrheal Disease among Children < 24 Months of Age in Moderate/High Mortality Regions of Sub-Saharan Africa and South Asia, Utilizing Data from the Global Enteric Multicenter Study (GEMS). | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2016-06-13T16:00:59Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 27219054 | - |
Appears in Collections: | Articles publicats en revistes (ISGlobal) |
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