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Title: The machinery underlying malaria parasite virulence is conserved between rodent and human malaria parasites
Author: Niz, Mariana De
Ullrich, Ann-Katrin
Heiber, Arlett
Blancke Soares, Alexandra
Pick, Christian
Lyck, Ruth
Keller, Derya
Kaiser, Gesine
Prado, Monica
Flemming, Sven
Portillo Obando, Hernando A. del
Janse, Chris J.
Heussler, Volker T.
Spielmann, Tobias
Keywords: Malalties parasitàries
Plasmodium falciparum
Parasitic diseases
Plasmodium falciparum
Issue Date: 26-May-2016
Publisher: Springer Nature
Abstract: Sequestration of red blood cells infected with the human malaria parasite Plasmodium falciparum in organs such as the brain is considered important for pathogenicity. A similar phenomenon has been observed in mouse models of malaria, using the rodent parasite Plasmodium berghei, but it is unclear whether the P. falciparum proteins known to be involved in this process are conserved in the rodent parasite. Here we identify the P. berghei orthologues of two such key factors of P. falciparum, SBP1 and MAHRP1. Red blood cells infected with P. berghei parasites lacking SBP1 or MAHRP1a fail to bind the endothelial receptor CD36 and show reduced sequestration and virulence in mice. Complementation of the mutant P. berghei parasites with the respective P. falciparum SBP1 and MAHRP1 orthologues restores sequestration and virulence. These findings reveal evolutionary conservation of the machinery underlying sequestration of divergent malaria parasites and support the notion that the P. berghei rodent model is an adequate tool for research on malaria virulence.
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It is part of: Nature Communications, 2016, vol. 7, num. 11659
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ISSN: 2041-1723
Appears in Collections:Articles publicats en revistes (ISGlobal)
Publicacions de projectes de recerca finançats per la UE

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