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2024-02-01

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cc-by-nc-nd (c) Varo, R. et al., 2024
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/217364

Adjunctive rosiglitazone treatment for severe pediatric malaria: A randomized placebo-controlled trial in Mozambican children

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Recurs relacionat

https://doi.org/10.1016/j.ijid.2023.11.031

Resum

Objectives: We tested the hypothesis that adjunctive rosiglitazone treatment would reduce levels of circulating angiopoietin-2 (Angpt-2) and improve outcomes of Mozambican children with severe malaria. Methods: A randomized, double-blind, placebo-controlled trial of rosiglitazone vs placebo as adjunctive treatment to artesunate in children with severe malaria was conducted. A 0.045 mg/kg/dose of rosiglitazone or matching placebo were administered, in addition to standard of malaria care, twice a day for 4 days. The primary endpoint was the rate of decline of Angpt-2 over 96 hours. Secondary outcomes included the longitudinal dynamics of angiopoietin-1 (Angpt-1) and the Angpt-2/Angpt-1 ratio over 96 hours, parasite clearance kinetics, clinical outcomes, and safety metrics. Results: Overall, 180 children were enrolled; 91 were assigned to rosiglitazone and 89 to placebo. Children who received rosiglitazone had a steeper rate of decline of Angpt-2 over the first 96 hours of hospitalization compared to children who received placebo; however, the trend was not significant (P = 0.28). A similar non-significant trend was observed for Angpt-1 (P = 0.65) and the Angpt-2/Angpt-1 ratio (P = 0.34). All other secondary and safety outcomes were similar between groups (P >0.05). Conclusion: Adjunctive rosiglitazone at this dosage was safe and well tolerated but did not significantly affect the longitudinal kinetics of circulating Angpt-2.

Matèries

Plasmodium falciparum, Malària, Malalties dels infants, Assaigs clínics, Antidiabètics

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Plasmodium falciparum, Malaria, Children's diseases, Clinical trials, Hypoglucemic agents

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Articles publicats en revistes (Medicina)
Articles publicats en revistes (ISGlobal)

Citació

VARO, Rosauro, CROWLEY, Valerie m., MUCASSE, Humberto, SITOE, Antonio, BRAMUGY, Justina, SERGHIDES, Lena, WECKMAN, Andrea m., ERICE, Clara, BILA, Rubao, VITORINO, Pio, MUCASSE, Campos, VALENTE, Marta, AJANOVIC, Sara, BALANZA LOMBARDIA, Núria, ZHONG, Kathleen, DERPSCH, Yiovanna, GLADSTONE, Melissa, MAYOR APARICIO, Alfredo gabriel, BASSAT ORELLANA, Quique, KAIN, Kevin c.. Adjunctive rosiglitazone treatment for severe pediatric malaria: A randomized placebo-controlled trial in Mozambican children. _International Journal of Infectious Diseases_. 2024. Vol. 139, núm. 34-40. [consulta: 15 de febrer de 2026]. ISSN: 1201-9712. [Disponible a: https://hdl.handle.net/2445/217364]

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