# name
Ultrasensitive multiplex optical quantification of bacteria in large samples of biofluids

# metadata.dc.description.abstract[].value
Efficient treatments in bacterial infections require the fast
                and accurate recognition of pathogens, with concentrations as
                low as one per milliliter in the case of septicemia. Detecting
                and quantifying bacteria in such low concentrations is
                challenging and typically demands cultures of large samples of
                blood (~1 milliliter) extending over 24-72 hours. This delay
                seriously compromises the health of patients. Here we
                demonstrate a fast microorganism optical detection system for
                the exhaustive identification and quantification of pathogens in
                volumes of biofluids with clinical relevance (~1 milliliter) in
                minutes. We drive each type of bacteria to accumulate antibody
                functionalized SERS-labelled silver nanoparticles. Particle
                aggregation on the bacteria membranes renders dense arrays of
                inter-particle gaps in which the Raman signal is exponentially
                amplified by several orders of magnitude relative to the
                dispersed particles. This enables a multiplex identification of
                the microorganisms through the molecule-specific spectral
                fingerprints.

# metadata.dc.relation.isformatof[].value
Reproducció del document publicat a:
                http://dx.doi.org/10.1038/srep29014

# metadata.dc.source[].value
Articles publicats en revistes (Medicina)

# metadata.dc.title[].value
Ultrasensitive multiplex optical quantification of bacteria in large samples of biofluids