# name
Pathologic Prognostic Factors in Endometrial Carcinoma (Other
                Than Tumor Type and Grade)

# metadata.dc.description.abstract[].value
Although endometrial carcinoma (EC) is generally
                considered to have a good prognosis, over 20% of women with EC
                die of their disease, with a projected increase in both
                incidence and mortality over the next few decades. The aim of
                accurate prognostication is to ensure that patients receive
                optimal treatment and are neither overtreated nor undertreated,
                thereby improving patient outcomes overall. Patients with EC can
                be categorized into prognostic risk groups based on
                clinicopathologic findings. Other than tumor type and grade,
                groupings and recommended management algorithms may take into
                account age, body mass index, stage, and presence of
                lymphovascular space invasion. The molecular classification of
                EC that has emerged from the Cancer Genome Atlas (TCGA) study
                provides additional, potentially superior, prognostic
                information to traditional histologic typing and grading. This
                classifier does not, however, replace clinicopathologic risk
                assessment based on parameters other than histotype and grade.
                It is envisaged that molecular and clinicopathologic prognostic
                grouping systems will work better together than either alone.
                Thus, while tumor typing and grading may be superseded by a
                classification based on underlying genomic abnormalities,
                accurate assessment of other pathologic parameters will continue
                to be key to patient management. These include those factors
                related to staging, such as depth of myometrial invasion,
                cervical, vaginal, serosal surface, adnexal and parametrial
                invasion, and those independent of stage such as lymphovascular
                space invasion. Other prognostic parameters will also be
                discussed. These recommendations were developed from the
                International Society of Gynecological Pathologists Endometrial
                Carcinoma project.

# metadata.dc.relation.ispartof[].value
International Journal of Gynecological Pathology, 2019, vol. 38 Suppl 1, p. :S93–S113

# metadata.dc.rights[].value
cc by (c) International Society of Gynecological Pathologists, 2019

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Pathologic Prognostic Factors in Endometrial Carcinoma (Other
                Than Tumor Type and Grade)