# name
Coarse-grained modelling applied to RNA morphologies and flexibility

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Treballs Finals de Grau de Física, Facultat de Física, Universitat de Barcelona, Curs: 2024, Tutors: Ignacio Pagonabarraga Mora, Modesto Orozco López

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Traditional methods in Molecular Dynamics are encountering their computational boundaries to simulate long-time periods and large macromolecules, such as RNA. We develop an alternative approach by using: i) an ultra-simplified coarse-grained (CG) representation of the molecule and ii) a flexible non-linear potential intended to represent the accessible conformational space of RNA. This model can reproduce the flexibility observed in force-field simulations and different morphologies can be modelled. These results underscore the necessity of non-linear dynamics and statistical physics in CG to capture the dynamic behaviour of Hydrogen Bonds in RNA.

# metadata.dc.title[].value
Coarse-grained modelling applied to RNA morphologies and flexibility