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Validation of whole-slide imaging in the primary diagnosis of liver biopsies in a University Hospital

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BACKGROUND: Experience in the use of whole slide imaging (WSI)
                for primary diagnosis is limited and there are no comprehensive
                reports evaluating this technology in liver biopsy specimens.
                AIMS: To determine the accuracy of interpretation of WSI
                compared with conventional light microscopy (CLM) in the
                diagnosis of needle liver biopsies. METHODS: Two experienced
                liver pathologists blindly analyzed 176 consecutive biopsies
                from the Pathology Department at the Hospital Clinic of
                Barcelona. One of the observers performed the initial evaluation
                with CLM, and the second evaluation with WSI, whereas the second
                observer performed the first evaluation with WSI and the second
                with CLM. All slides were digitized in a Ventana iScan HT at
                400x and evaluated with the Virtuoso viewer (Roche diagnostics).
                We used kappa statistics (kappa) for two observations. RESULTS:
                Intra-observer agreement between WSI and CLM evaluations was
                almost perfect (96.6%, kappa=0.9; 95% confidence interval [95%
                CI]: 0.9-1 for observer 1, and 90.3%, kappa=0.9; 95%CI: 0.8-0.9
                for observer 2). Both native and transplantation biopsies showed
                an almost perfect concordance in the diagnosis. CONCLUSION:
                Diagnosis of needle liver biopsy specimens using WSI is
                accurate. This technology can reliably be introduced in routine
                diagnosis.

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Reproducció del document publicat a:                 http://dx.doi.org/10.1016/j.dld.2017.07.002

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Digestive and Liver Disease, 2017, vol. , num. , p. Ahead of print

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Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Validation of whole-slide imaging in the primary diagnosis of liver biopsies in a University Hospital