# name
Prevalence, antimicrobial resistance and serotype distribution
                of group B streptococcus isolated among pregnant women and
                newborns in Rabat, Morocco

# metadata.dc.description.abstract[].value
PURPOSE: Group B streptococcus (GBS) is an important cause of
                neonatal sepsis worldwide. Data on the prevalence of maternal
                GBS colonization, risk factors for carriage, antibiotic
                susceptibility and circulating serotypes are necessary to tailor
                adequate locally relevant public health policies. METHODOLOGY: A
                prospective study including pregnant women and their newborns
                was conducted between March and July 2013 in Morocco. We
                collected clinical data and vagino-rectal and urine samples from
                the recruited pregnant women, together with the clinical
                characteristics of, and body surface samples from, their
                newborns. Additionally, the first three newborns admitted every
                day with suspected invasive infection were recruited for a
                thorough screening for neonatal sepsis. Serotypes were
                characterized by molecular testing. RESULTS: A total of 350
                pregnant women and 139 of their newborns were recruited. The
                prevalence of pregnant women colonized by GBS was 24 %. In 5/160
                additional sick newborns recruited with suspected sepsis, the
                blood cultures were positive for GBS. Gestational hypertension
                and vaginal pruritus were significantly associated with a
                vagino-rectal GBS colonization in univariate analyses. All of
                the strains were susceptible to penicillin, while 7 % were
                resistant to clindamycin and 12 % were resistant to
                erythromycin. The most common GBS serotypes detected included V,
                II and III. CONCLUSION: In Morocco, maternal GBS colonization is
                high. Penicillin can continue to be the cornerstone of
                intrapartum antibiotic prophylaxis. A pentavalent GBS vaccine
                (Ia, Ib, II, III and V) would have been effective against the
                majority of the colonizing cases in this setting, but a
                trivalent one (Ia, Ib and III) would only prevent 28 % of the
                cases.

# metadata.dc.relation.isformatof[].value
Versió postprint del document publicat a:
                http://dx.doi.org/10.1099/jmm.0.000720

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Prevalence, antimicrobial resistance and serotype distribution
                of group B streptococcus isolated among pregnant women and
                newborns in Rabat, Morocco