# name
High production of pro-inflammatory cytokines by maternal blood
                mononuclear cells is associated with reduced maternal malaria
                but increased cord blood infection

# metadata.dc.description.abstract[].value
BACKGROUND: Increased susceptibility to malaria during pregnancy
                is not completely understood. Cellular immune responses mediate
                both pathology and immunity but the effector responses involved
                in these processes have not been fully characterized. Maternal
                and fetal cytokine and chemokine responses to malaria at
                delivery, and their association with pregnancy and childhood
                outcomes, were investigated in 174 samples from a mother and
                child cohort from Mozambique. Peripheral and cord mononuclear
                cells were stimulated with Plasmodium falciparum lysate and
                secretion of IL-12p70, IFN-gamma, IL-2, IL-10, IL-8, IL-6, IL-4,
                IL-5, IL-1beta, TNF, TNF-beta was quantified in culture
                supernatants by multiplex flow cytometry while cellular mRNA
                expression of IFN-gamma, TNF, IL-2, IL-4, IL-6, IL-10 and IL-13
                was measured by quantitative PCR. RESULTS: Higher concentrations
                of IL-6 and IL-1beta were associated with a reduced risk of P.
                falciparum infection in pregnant women (p < 0.049).
                Pro-inflammatory cytokines IL-6, IL-1beta and TNF strongly
                correlated among themselves (rho > 0.5, p < 0.001). Higher
                production of IL-1beta was significantly associated with
                congenital malaria (p < 0.046) and excessive TNF was
                associated with peripheral infection and placental lesions (p
                < 0.044). CONCLUSIONS: Complex network of immuno-pathological
                cytokine mechanisms in the placental and utero environments
                showed a potential trade-off between positive and negative
                effects on mother and newborn susceptibility to infection.

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
High production of pro-inflammatory cytokines by maternal blood
                mononuclear cells is associated with reduced maternal malaria
                but increased cord blood infection