# name
Lifetime occupational exposure to metals and welding fumes, and
                risk of glioma: a 7-country population-based case-control study

# metadata.dc.description.abstract[].value
BACKGROUND: Brain tumor etiology is poorly understood. Based on
                their ability to pass through the blood-brain barrier, it has
                been hypothesized that exposure to metals may increase the risk
                of brain cancer. Results from the few epidemiological studies on
                this issue are limited and inconsistent. METHODS: We
                investigated the relationship between glioma risk and
                occupational exposure to five metals - lead, cadmium, nickel,
                chromium and iron- as well as to welding fumes, using data from
                the seven-country INTEROCC study. A total of 1800 incident
                glioma cases and 5160 controls aged 30-69 years were included in
                the analysis. Lifetime occupational exposure to the agents was
                assessed using the INTEROCC JEM, a modified version of the
                Finnish job exposure matrix FINJEM. RESULTS: In general, cases
                had a slightly higher prevalence of exposure to the various
                metals and welding fumes than did controls, with the prevalence
                among ever exposed ranging between 1.7 and 2.2% for cadmium to
                10.2 and 13.6% for iron among controls and cases, respectively.
                However, in multivariable logistic regression analyses, there
                was no association between ever exposure to any of the agents
                and risk of glioma with odds ratios (95% confidence intervals)
                ranging from 0.8 (0.7-1.0) for lead to 1.1 (0.7-1.6) for
                cadmium. Results were consistent across models considering
                cumulative exposure or duration, as well as in all sensitivity
                analyses conducted. CONCLUSIONS: Findings from this large-scale
                international study provide no evidence for an association
                between occupational exposure to any of the metals under
                scrutiny or welding fumes, and risk of glioma.

# metadata.dc.relation.isformatof[].value
Reproducció del document publicat a:
                http://dx.doi.org/10.1186/s12940-017-0300-y

# metadata.dc.relation.ispartof[].value
Environmental Health, 2017, vol. 16, num. 1, p. 90

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Lifetime occupational exposure to metals and welding fumes, and
                risk of glioma: a 7-country population-based case-control study