# name
Plasmodium vivax Populations Are More Genetically Diverse and
                Less Structured than Sympatric Plasmodium falciparum Populations

# metadata.dc.description.abstract[].value
INTRODUCTION: The human malaria parasite, Plasmodium vivax, is
                proving more difficult to control and eliminate than Plasmodium
                falciparum in areas of co-transmission. Comparisons of the
                genetic structure of sympatric parasite populations may provide
                insight into the mechanisms underlying the resilience of P.
                vivax and can help guide malaria control programs.
                METHODOLOGY/PRINCIPLE FINDINGS: P. vivax isolates representing
                the parasite populations of four areas on the north coast of
                Papua New Guinea (PNG) were genotyped using microsatellite
                markers and compared with previously published microsatellite
                data from sympatric P. falciparum isolates. The genetic
                diversity of P. vivax (He = 0.83-0.85) was higher than that of
                P. falciparum (He = 0.64-0.77) in all four populations. Moderate
                levels of genetic differentiation were found between P.
                falciparum populations, even over relatively short distances
                (less than 50 km), with 21-28% private alleles and clear
                geospatial genetic clustering. Conversely, very low population
                differentiation was found between P. vivax catchments, with less
                than 5% private alleles and no genetic clustering observed. In
                addition, the effective population size of P. vivax (30353;
                13043-69142) was larger than that of P. falciparum (18871;
                8109-42986). CONCLUSIONS/SIGNIFICANCE: Despite comparably high
                prevalence, P. vivax had higher diversity and a panmictic
                population structure compared to sympatric P. falciparum
                populations, which were fragmented into subpopulations. The
                results suggest that in comparison to P. falciparum, P. vivax
                has had a long-term large effective population size, consistent
                with more intense and stable transmission, and limited impact of
                past control and elimination efforts. This underlines
                suggestions that more intensive and sustained interventions will
                be needed to control and eventually eliminate P. vivax. This
                research clearly demonstrates how population genetic analyses
                can reveal deeper insight into transmission patterns than
                traditional surveillance methods.

# metadata.dc.relation.isformatof[].value
Reproducció del document publicat a:      http://dx.doi.org/10.1371/journal.pntd.0003634

# metadata.dc.relation.ispartof[].value
PLoS Neglected Tropical Diseases, 2015, vol. 9, num. 4, p. e0003634

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Plasmodium vivax Populations Are More Genetically Diverse and
                Less Structured than Sympatric Plasmodium falciparum Populations