# name
Defining the next generation of Plasmodium vivax diagnostic
                tests for control and elimination: Target product profiles

# metadata.dc.description.abstract[].value
The global prevalence of malaria has decreased over the past
                fifteen years, but similar gains have not been realized against
                Plasmodium vivax because this species is less responsive to
                conventional malaria control interventions aimed principally at
                P. falciparum. Approximately half of all malaria cases outside
                of Africa are caused by P. vivax. This species places dormant
                forms in human liver that cause repeated clinical attacks
                without involving another mosquito bite. The diagnosis of acute
                patent P. vivax malaria relies primarily on light microscopy.
                Specific rapid diagnostic tests exist but typically perform
                relatively poorly compared to those for P. falciparum. Better
                diagnostic tests are needed for P. vivax. To guide their
                development, FIND, in collaboration with P. vivax experts,
                identified the specific diagnostic needs associated with this
                species and defined a series of three distinct target product
                profiles, each aimed at a particular diagnostic application: (i)
                point-of-care of acutely ill patients for clinical care
                purposes; (ii) point-of-care asymptomatic and otherwise
                sub-patent residents for public health purposes, e.g., mass
                screen and treat campaigns; and (iii) ultra-sensitive not
                point-of-care diagnosis for epidemiological
                research/surveillance purposes. This report presents and
                discusses the rationale for these P. vivax-specific diagnostic
                target product profiles. These contribute to the rational
                development of fit-for-purpose diagnostic tests suitable for the
                clinical management, control and elimination of P. vivax
                malaria.

# metadata.dc.relation.isformatof[].value
Reproducció del document publicat a:
                http://dx.doi.org/10.1371/journal.pntd.0005516

# metadata.dc.relation.ispartof[].value
PLoS Neglected Tropical Diseases, 2017, vol. 11, num. 4, p.
                e0005516

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Defining the next generation of Plasmodium vivax diagnostic
                tests for control and elimination: Target product profiles