# name
Febrile Illness Evaluation in a Broad Range of Endemicities
                (FIEBRE): protocol for a multisite prospective observational
                study of the causes of fever in Africa and Asia.

# metadata.dc.description.abstract[].value
INTRODUCTION NlmCategory: BACKGROUND content:
Fever commonly leads to healthcare seeking and hospital
admission in sub-Saharan Africa and Asia. There is only limited
guidance for clinicians managing non-malarial fevers, which
                often results in inappropriate treatment for patients.
                Furthermore, there is little evidence for estimates of disease
                burden, or to guide empirical therapy, control measures,
                resource allocation, prioritisation of clinical diagnostics or
                antimicrobial stewardship. The Febrile Illness Evaluation in a
                Broad Range of Endemicities (FIEBRE) study seeks to address
                these information gaps. - Label: METHODS AND ANALYSIS
                NlmCategory: UNASSIGNED content: FIEBRE investigates febrile
                illness in paediatric and adult outpatients and inpatients using
                standardised clinical, laboratory and social science protocols
                over a minimum 12-month period at five sites in sub-Saharan
                Africa and Southeastern and Southern Asia. Patients presenting
                with fever are enrolled and provide clinical data, pharyngeal
                swabs and a venous blood sample; selected participants also
                provide a urine sample. Laboratory assessments target infections
                that are treatable and/or preventable. Selected point-of-care
                tests, as well as blood and urine cultures and antimicrobial
                susceptibility testing, are performed on site. On day 28,
                patients provide a second venous blood sample for serology and
                information on clinical outcome. Further diagnostic assays are
                performed at international reference laboratories. Blood and
                pharyngeal samples from matched community controls enable
                calculation of AFs, and surveys of treatment seeking allow
                estimation of the incidence of common infections. Additional
                assays detect markers that may differentiate bacterial from
                non-bacterial causes of illness and/or prognosticate illness
                severity. Social science research on antimicrobial use will
                inform future recommendations for fever case management.
                Residual samples from participants are stored for future use. -
                Label: ETHICS AND DISSEMINATION NlmCategory: UNASSIGNED content:
                Ethics approval was obtained from all relevant institutional and
                national committees; written informed consent is obtained from
                all participants or parents/guardians. Final results will be
                shared with participating communities, and in open-access
                journals and other scientific fora. Study documents are
                available online (https://doi.org/10.17037/PUBS.04652739).

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Febrile Illness Evaluation in a Broad Range of Endemicities
                (FIEBRE): protocol for a multisite prospective observational
                study of the causes of fever in Africa and Asia.