# name
Investigation of DNA repair-related SNPs underlying
                susceptibility to papillary thyroid carcinoma reveals MGMT as a
                novel candidate gene in Belarusian children exposed to radiation

# metadata.dc.description.abstract[].value
BACKGROUND: Genetic factors may influence an individual's
                sensitivity to ionising radiation and therefore modify his/her
                risk of developing papillary thyroid carcinoma (PTC).
                Previously, we reported that common single nucleotide
                polymorphisms (SNPs) within the DNA damage recognition gene ATM
                contribute to PTC risk in Belarusian children exposed to fallout
                from the Chernobyl power plant accident. Here we explored in the
                same population the contribution of a panel of DNA
                repair-related SNPs in genes acting downstream of ATM. METHODS:
                The association of 141 SNPs located in 43 DNA repair genes was
                examined in 75 PTC cases and 254 controls from the Gomel region
                in Belarus. All subjects were younger than 15 years at the time
                of the Chernobyl accident. Conditional logistic regressions
                accounting for radiation dose were performed with PLINK using
                the additive allelic inheritance model, and a linkage
                disequilibrium (LD)-based Bonferroni correction was used for
                correction for multiple testing. RESULTS: The intronic SNP
                rs2296675 in MGMT was associated with an increased PTC risk [per
                minor allele odds ratio (OR) 2.54 95% CI 1.50, 4.30, P per
                allele = 0.0006, P corr.= 0.05], and gene-wide association
                testing highlighted a possible role for ERCC5 (P Gene = 0.01)
                and PCNA (P Gene = 0.05) in addition to MGMT (P Gene = 0.008).
                CONCLUSIONS: These findings indicate that several genes acting
                in distinct DNA repair mechanisms contribute to PTC risk.
                Further investigation is needed to decipher the functional
                properties of the methyltransferase encoded by MGMT and to
                understand how alteration of such functions may lead to the
                development of the most common type of thyroid cancer.

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.subject.other[].value
Physiological effects of radiation | Physiological effects of radiation

# metadata.dc.title[].value
Investigation of DNA repair-related SNPs underlying
                susceptibility to papillary thyroid carcinoma reveals MGMT as a
                novel candidate gene in Belarusian children exposed to radiation