# name
Plasmodium vivax VIR Proteins Are Targets of Naturally-Acquired
                Antibody and T Cell Immune Responses to Malaria in Pregnant
                Women

# metadata.dc.description[].value
Podeu consultar dades primàries associades a l'article a: http://hdl.handle.net/2445/101775

# metadata.dc.description.abstract[].value
P. vivax infection during pregnancy has been associated with
                poor outcomes such as anemia, low birth weight and congenital
                malaria, thus representing an important global health problem.
                However, no vaccine is currently available for its prevention.
                Vir genes were the first putative virulent factors associated
                with P. vivax infections, yet very few studies have examined
                their potential role as targets of immunity. We investigated the
                immunogenic properties of five VIR proteins and two long
                synthetic peptides containing conserved VIR sequences (PvLP1 and
                PvLP2) in the context of the PregVax cohort study including
                women from five malaria endemic countries: Brazil, Colombia,
                Guatemala, India and Papua New Guinea (PNG) at different
                timepoints during and after pregnancy. Antibody responses
                against all antigens were detected in all populations, with PNG
                women presenting the highest levels overall. P. vivax infection
                at sample collection time was positively associated with
                antibody levels against PvLP1 (fold-increase: 1.60 at
                recruitment -first antenatal visit-) and PvLP2 (fold-increase:
                1.63 at delivery), and P. falciparum co-infection was found to
                increase those responses (for PvLP1 at recruitment,
                fold-increase: 2.25). Levels of IgG against two VIR proteins at
                delivery were associated with higher birth weight (27 g increase
                per duplicating antibody levels, p<0.05). Peripheral blood
                mononuclear cells from PNG uninfected pregnant women had
                significantly higher antigen-specific IFN-gamma TH1 responses
                (p=0.006) and secreted less pro-inflammatory cytokines TNF and
                IL-6 after PvLP2 stimulation than P. vivax-infected women
                (p<0.05). These data demonstrate that VIR antigens induce the
                natural acquisition of antibody and T cell memory responses that
                might be important in immunity to P. vivax during pregnancy in
                very diverse geographical settings.

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Reproducció del document publicat a:
                http://dx.doi.org/10.1371/journal.pntd.0005009

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PLoS Neglected Tropical Diseases, 2016, vol. 10, num. 10, p.
                e0005009

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Plasmodium vivax VIR Proteins Are Targets of Naturally-Acquired
                Antibody and T Cell Immune Responses to Malaria in Pregnant
                Women