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Tuberculosis-HIV co-infection: Progress and challenges after two decades of global antiretroviral treatment roll-out

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Despite wide antiretroviral scale-up during the past two decades resulting in declining new infections and mortality globally, HIV-associated tuberculosis remains as a major public health concern. Tuberculosis is the leading HIV-associated opportunistic infection and the main cause of death globally and, particularly, in resource-limited settings. Several challenges exist regarding diagnosis, global implementation of latent tuberculosis treatment, management of active tuberculosis, delivery of optimal patient-centered TB and HIV prevention and care in high burden countries. In this article we review the advances on pathogenesis, diagnosis, and treatment after nearly two decades of global roll-out of antiretroviral therapy and discuss the current challenges for the global control of tuberculosis-HIV co-infection.

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Archivos de Bronconeumologia, 2020, vol. 56, num. 7, p. 446-454

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Articles publicats en revistes (Medicina)

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Tuberculosis-HIV co-infection: Progress and challenges after two decades of global antiretroviral treatment roll-out