# name
Genetic control of neuronal activity enhances axonal growth only on permissive substrates

# metadata.dc.description.abstract[].value
Abstract
                Background
                Neural tissue has limited regenerative ability. To cope with that, in recent years a diverse set of novel tools has been used to tailor neurostimulation therapies and promote functional regeneration after axonal injuries.
              
                Method
                In this report, we explore cell-specific methods to modulate neuronal activity, including opto- and chemogenetics to assess the effect of specific neuronal stimulation in the promotion of axonal regeneration after injury.
              
                Results
                Opto- and chemogenetic stimulations of neuronal activity elicited increased in vitro neurite outgrowth in both sensory and cortical neurons, as well as in vivo regeneration in the sciatic nerve, but not after spinal cord injury. Mechanistically, inhibitory substrates such as chondroitin sulfate proteoglycans block the activity induced increase in axonal growth.
              
                Conclusions
                We found that genetic modulations of neuronal activity on both dorsal root ganglia and corticospinal motor neurons increase their axonal growth capacity but only on permissive environments.

# metadata.dc.identifier.citation[].value
Mesquida-Veny, Francina;Martínez-Torres, Sara;del Rio, Jose Antonio;Hervera, Arnau. Genetic control of neuronal activity enhances axonal growth only on permissive substrates. Molecular Medicine, 2022, 28, 1-97

# metadata.dc.rights[].value
cc by (c) Mesquida Veny, Francina et al., 2022

# metadata.dc.source[].value
Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))

# metadata.dc.title[].value
Genetic control of neuronal activity enhances axonal growth only on permissive substrates