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CARM1 and BAF155: an example of how chromatin remodeling factors can be relocalized and contribute to cancer

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In a recent article, Wang and colleagues reported the discovery of a mechanism by which CARM1 regulates the genomic localization of BAF155 (a SWI/SNF subunit involved in chromatin remodeling) through post-translational methylation at R1064 arginine residues. This modification leads to the relocalization of BAF155-containing SWI/SNF complexes to regions containing genes involved in the Myc oncogenic pathway. The results presented are evidence that these interactions constitute a mechanism by which the BAF155 chromatin remodeling factor contributes to cancer.

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Breast Cancer Research, 2014, vol. 16, num. 3, p. 307

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cc-by (c) Stefansson, Olafur A. et al., 2014

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Articles publicats en revistes (Ciències Fisiològiques)

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CARM1 and BAF155: an example of how chromatin remodeling factors can be relocalized and contribute to cancer