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Urban Dust Microbiome: Impact on Later Atopy and Wheezing

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INTRODUCTION: Investigations in urban areas have just begun to
                explore how the indoor dust microbiome may affect the
                pathogenesis of asthma and allery. We aimed to investigate the
                early fungal and bacterial microbiome in house dust with
                allergic sensitization and wheezing later in childhood. METHODS:
                Individual dust samples from 189 homes of the LISAplus birth
                cohort study were collected shortly after birth from living room
                floors and profiled for fungal and bacterial microbiome. Fungal
                and bacterial diversity was assessed with terminal restriction
                fragment length polymorphism (tRFLP) and defined by the Simpson
                diversity index. Information on wheezing outcomes and
                co-variates until the age of 10 years was obtained by parental
                questionnaires. Information on specific allergic sensitization
                was available at 6 and 10 years. Logistic regression and General
                Estimation Equation (GEE) models were used to examine the
                relationship between microbial diversity and health outcomes.
                RESULTS: Logistic regression analyses revealed a significantly
                reduced risk of developing sensitization to aero-allergens at 6
                years and ever wheezing until the age of 10 years for exposure
                to higher fungal diversity (adjusted Odds Ratio aOR (95%CI):
                0.26 (0.10-0.70)), and 0.42 (0.18-0.96), respectively), in
                adjusted analyses. The associations were attenuated for the
                longitudinal analyses (GEE) until the age of 10 years. There was
                no association between higher exposure to bacterial diversity
                and the tested health outcomes. CONCLUSION: Higher early
                exposure to fungal diversity might help to prevent from
                developing sensitization to aero-allergens in early childhood,
                but the reasons for attenuated effects in later childhood
                require further prospective studies.

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National Institute of Environmental Health Sciences (NIEHS)

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Versió postprint del document publicat a:
                http://dx.doi.org/10.1289/EHP158

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Urban Dust Microbiome: Impact on Later Atopy and Wheezing