# name
Membrane Vesicles from the Gut Microbiota and Their Interactions with the Host

# metadata.dc.description.abstract[].value
Gut microbiota plays an essential role in maintaining intestinal homeostasis and human health. Microbiota establishes a complex network of dynamic and reciprocal interactions with the intestinal epithelium and immune system. The mucin layer that covers the epithelium prevents luminal bacteria from accessing host cells. Thus, microbiota–host communication mainly relies on secreted factors and membrane vesicles (MVs), which can cross the inner mucus layer and reach the epithelium. This chapter focuses on the role of microbiota-secreted MVs as key players in signaling processes in the intestinal mucosa. This is an emerging research topic, with the first reports dating from 2012. Microbiota-derived MVs are involved in interspecies communication in the gut, between bacteria and between microbiota and host. Here we present current knowledge on the mechanisms used by microbiota MVs to assist and control the gut microbial community and to modulate host immune and defense responses. Constant stimulation of immune receptors by microbiota MVs results in tightly controlled inflammation that contributes to tolerogenic responses essential to maintaining intestinal homeostasis. Moreover, gut microbiota MVs are emerging as physical vehicles for distribution and delivery of bacterial effectors to distal tissues in human health and disease.

# metadata.dc.relation.ispartof[].value
In: Kaparakis-Liaskos M., Kufer T. (eds). Bacterial Membrane Vesicles. Biogenesis, Functions and Applications. Springer Nature. Cham. 01 April 2020. [Print ISBN 978-3-030-36330-7, Online ISBN 978-3-030-36331-4]. http://doi.org/10.1007/978-3-030-36331-4. Chapter 9, Pages 189-217.

# metadata.dc.source[].value
Llibres / Capítols de llibre (Bioquímica i Fisiologia)

# metadata.dc.title[].value
Membrane Vesicles from the Gut Microbiota and Their Interactions with the Host