# name
Radiological findings in young children investigated for tuberculosis in Mozambique

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INTRODUCTION: Chest radiography remains a critical tool for
                diagnosing intrathoracic tuberculosis (TB) in young children who
                are unable to expectorate. We describe the radiological findings
                in children under 3 years of age investigated for TB in the
                district of Manhica, southern Mozambique, an area with a high
                prevalence of TB and HIV. METHODS: Digital antero-posterior and
                lateral projections were performed and reviewed by two
                independent readers, using a standardized template. Readers
                included a local pediatrician and a pediatric radiologist
                blinded to all clinical information. International consensus
                case definitions for intra-thoracic TB in children were applied.
                RESULTS: A total of 766 children were evaluated of whom 43
                (5.6%) had TB. The most frequent lesion found in TB cases was
                air space consolidation (65.1%), followed by suggestive hilar
                lymphadenopathy (17.1%) and pleural effusion (7.0%). Air space
                consolidation was significantly more common in TB cases than in
                non-TB cases (odds ratio 8.9; 95% CI: 1.6-50.5), as were hilar
                lymphadenopathy (OR 17.2; 95% CI: 5.7-52.1). The only case with
                miliary infiltrates and 3 with pleural effusions occurred in
                HIV-infected children. CONCLUSION: Frequent air space
                consolidation complicates radiological distinction between TB
                and bacterial pneumonia in young children, underscoring the need
                for epidemiological contextualization and consideration of all
                relevant signs and symptoms.

# metadata.dc.relation.isformatof[].value
Reproducció del document publicat a:
                http://dx.doi.org/10.1371/journal.pone.0127323

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Radiological findings in young children investigated for tuberculosis in Mozambique